ArticleEnvironmental health perspectives2016
U-Shaped Association between Plasma Manganese Levels and Type 2 Diabetes.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 82 citations in OpenAlex.
- Association of serum element levels with cardiovascular diseases and type 2 diabetes mellitus risk in a Kurdish population of western Iran.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Serum Manganese, Cobalt, Copper, Zinc, Selenium, and Iodine Levels, and the Incidence of Type 2 Diabetes: A Nested Case-control Study.Biological trace element research · 2026Article
- Persistent effects of pre-differentiation manganese exposure on adipogenesis and metabolic function in differentiated 3T3-L1 adipocyte cells.Journal of hazardous materials advances · 2026Article
- Trace Elements in the Pancreas: From Physiological Homeostasis to the Pathogenesis of Diabetes, Pancreatitis, and Cancer-A Review.Life (Basel, Switzerland) · 2026Review
- Prenatal exposure to essential and toxic elements in relation to infant growth trajectories.Environmental health : a global access science source · 2026Article
- Heavy metals and mortality in cardiovascular-kidney-metabolic syndrome: Insights from the NHANES cohort.Medicine · 2025Article
- Concentrations of trace metals in serum: Implications for type 2 diabetes mellitus and gender difference.Environmental analysis, health and toxicology · 2025Article
- Association between blood manganese and cardiovascular diseases among U.S. adult population.Scientific reports · 2024Article
- Association Between Serum Concentrations of (Certain) Metals and Type 2 Diabetes Mellitus.Journal of clinical medicine · 2024Review
- Machine learning uncovers manganese as a key nutrient associated with reduced risk of steatotic liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2024Article
- Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth.Maternal & child nutrition · 2024Article
- The relationship between serum manganese concentration with all-cause and cause-specific mortality: a retrospective and population-based cross-sectional study.BMC cardiovascular disorders · 2024Article
- Associations between patterns of blood heavy metal exposure and health outcomes: insights from NHANES 2011-2016.BMC public health · 2024Article
- Associations between metals and metabolomic profiles related to diabetes among adults in a rural region.Environmental research · 2024Article
- A review of common statistical methods for dealing with multiple pollutant mixtures and multiple exposures.Frontiers in public health · 2024Review
- Manganese - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Blood manganese and non-alcoholic fatty liver disease in a high manganese exposure area in China.Journal of health, population, and nutrition · 2023Article
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- The Link between Trace Metal Elements and Glucose Metabolism: Evidence from Zinc, Copper, Iron, and Manganese-Mediated Metabolic Regulation.Metabolites · 2023Review
- Joint Effect of Multiple Metals on Hyperuricemia and Their Interaction with Obesity: A Community-Based Cross-Sectional Study in China.Nutrients · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundManganese is both an essential element and a known toxicant, and it plays important roles in many mechanisms in relation to type 2 diabetes (T2D). However, epidemiological studies of this relationship are rare.
objectiveWe investigated the association between plasma manganese and newly diagnosed T2D as well as whether the association could be modified by manganese superoxide dismutase (MnSOD) polymorphisms.
methodsWe conducted a case-control study of 3,228 participants in China: 1,614 T2D patients and 1,614 controls. Concentrations of plasma magnesium were measured, and all participants were genotyped for the MnSOD Val16Ala polymorphism (rs4880).
resultsA U-shaped association was observed between plasma manganese and T2D, with increased odds ratios (ORs) in relation to either low or high plasma manganese levels. Compared with the middle tertile, the multivariate-adjusted ORs [95% confidence intervals (CIs)] of T2D associated with the lowest tertile and the highest tertile of plasma manganese were 1.89 (1.53, 2.33) and 1.56 (1.23, 1.97), respectively. In spline analysis, the U-shaped association was consistently indicated, with the lowest odds of T2D at the plasma manganese concentration of 4.95 μg/L. Minor allele frequencies (C allele) of the MnSOD Val16Ala polymorphism (rs4880) in the normal glucose tolerance (NGT) and the T2D groups were 13.57% and 14.50%, respectively. The MnSOD rs4880 polymorphism was not associated with T2D, and no interaction was found between plasma manganese and the MnSOD rs4880 polymorphism in relation to T2D.
conclusionsOur results suggested a U-shaped association between plasma manganese and T2D; both low and high levels of plasma manganese were associated with higher odds of newly diagnosed T2D. The U-shaped association was not modified by the MnSOD rs4880 polymorphism. Citation: Shan Z, Chen S, Sun T, Luo C, Guo Y, Yu X, Yang W, Hu FB, Liu L. 2016. U-shaped association between plasma manganese levels and type 2 diabetes. Environ Health Perspect 124:1876-1881; http://dx.doi.org/10.1289/EHP176.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.