ArticleEnvironmental health perspectives2016
Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review and meta-analysis on the health effects of long-term exposure to ultrafine particles.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Characteristics of cohort studies of long-term exposure to PMEnvironmental science and pollution research international · 2019Pooled it
- Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence.International journal of public health · 2019Pooled it
- Effect of Reducing Ambient Traffic-Related Air Pollution on Blood Pressure: A Randomized Crossover Trial.Hypertension (Dallas, Tex. : 1979) · 2021Trial
- Short-term effects of haze exposure on clinical and subclinical cardiovascular indicators among adults in Nanjing.Scientific reports · 2026Article
- Metabolic Signatures of Air Pollution and Major Adverse Cardiovascular Events in Patients Undergoing Cardiac Catheterization.JACC. Advances · 2026Article
- Associations of time-weighted individual exposure to ambient particulate matter with carotid atherosclerosis in Beijing, China.Environmental health : a global access science source · 2023Article
- Spatiotemporal Heterogeneity of Lung-Deposited Surface Area in Zurich Switzerland: Lung-Deposited Surface Area as a New Routine Metric for Ambient Particle Monitoring.International journal of public health · 2023Article
- Assessing and Validating the Ability of Machine Learning to Handle Unrefined Particle Air Pollution Mobile Monitoring Data Randomly, Spatially, and Spatiotemporally.International journal of environmental research and public health · 2022Article
- A randomized crossover trial of HEPA air filtration to reduce cardiovascular risk for near highway residents: Methods and approach.Contemporary clinical trials · 2021Article
- The critical role of endothelial function in fine particulate matter-induced atherosclerosis.Particle and fibre toxicology · 2020Review
- Short-term effects of outdoor air pollution on acute ischaemic stroke occurrence: a case-crossover study in Tianjin, China.Occupational and environmental medicine · 2020Article
- The aryl hydrocarbon receptor as a target of environmental stressors - Implications for pollution mediated stress and inflammatory responses.Redox biology · 2020Review
- Ambient PM2.5 and Annual Lung Cancer Incidence: A Nationwide Study in 295 Chinese Counties.International journal of environmental research and public health · 2020Article
- Ultrafine Particle Number Concentration Model for Estimating Retrospective and Prospective Long-Term Ambient Exposures in Urban Neighborhoods.Environmental science & technology · 2020Article
- Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project.International journal of epidemiology · 2020Article
- Complex contaminant mixtures and their associations with intima-media thickness.BMC cardiovascular disorders · 2019Article
- THE EXPOSOME IN HUMAN EVOLUTION: FROM DUST TO DIESEL.The Quarterly review of biology · 2019Article
- Associations of ambient PMInternational journal of biometeorology · 2019Article
- Inflammatory marker and aryl hydrocarbon receptor-dependent responses in human macrophages exposed to emissions from biodiesel fuels.Chemosphere · 2019Article
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17 authors.
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Abstract
backgroundSubclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear.
objectivesWe investigated the association of long-term exposure to PM10 (≤ 10 μm), PM2.5 (≤ 2.5 μm: total mass, vehicular, and crustal sources), and ultrafine particles [UFP < 0.1 μm: particle number concentration (PNC) and lung-deposited surface area (LDSA)] with carotid intima-media thickness (CIMT).
methodsWe used data from 1,503 participants ≥ 50 years old who participated in the third examination of the Swiss SAPALDIA cohort. Exposures were obtained from dispersion models and land-use regression models. Covariate information, including previous cardiovascular risk factors, was obtained from the second and third SAPALDIA examinations.
resultsThe adjusted percent difference in CIMT associated with an exposure contrast between the 10th and 90th percentile was 1.58% (95% CI: -0.30, 3.47%) for PM10, 2.10% (95% CI: 0.04, 4.16%) for PM2.5, 1.67% (95% CI: -0.13, 3.48%) for the vehicular source of PM2.5, -0.58% (95% CI: -3.95, 2.79%) for the crustal source of PM2.5, 2.06% (95% CI: 0.03, 4.10%) for PNC, and 2.32% (95% CI: 0.23, 4.40%) for LDSA. Stronger associations were observed among diabetics, subjects with low-educational level, and those at higher cardiovascular risk.
conclusionsCIMT was associated with exposure to PM10, PM2.5, and UFP. The PM2.5 source-specific analysis showed a positive association for the vehicular source but not for the crustal source. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. Citation: Aguilera I, Dratva J, Caviezel S, Burdet L, de Groot E, Ducret-Stich RE, Eeftens M, Keidel D, Meier R, Perez L, Rothe T, Schaffner E, Schmit-Trucksäss A, Tsai MY, Schindler C, Künzli N, Probst-Hensch N. 2016. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study. Environ Health Perspect 124:1700-1706; http://dx.doi.org/10.1289/EHP161.
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