Evidence map›Paper›PMID 27258529›Full record

Observational studyMedicine2016

Outcomes of 50 Patients With Ewing Sarcoma Family of Tumors Treated at a Single Institution in Taiwan.

Chih-Ying Lee, Chueh-Chuan Yen, Hsiu-Ju Yen, Cheng-Ying Shiau, Ta-Chung Chao, Po-Kuei Wu, Cheng-Fong Chen, Paul Chih-Hsueh Chen, Hung-Ta Hondar Wu, Hong-Jen Chiou and 3 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Unusual presentation of Ewing sarcoma; a case report and literature review.International journal of surgery case reports · 2022
    Article
  5. Article
  6. Surgical Resection of Primary Ewing's Sarcoma of Bone Improves Overall Survival in Patients Presenting with Metastasis.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  7. Article
  8. Article
  9. Clinicopathological Features and Treatment Outcomes in Ewing's Sarcoma Patients: A 10-year experience of Alexandria Clinical Oncology Department.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chih-Ying LeeFrom the Division of Pediatric Hematology and Oncology (C-YL, H-JY, C-CC, G-YH), Department of Pediatrics, Taipei Veterans General Hospital; School of Medicine (C-YL, C-CY, H-JY, C-YS, T-CC, P-KW, C-FC, PC-HC, H-THW, H-JC, C-CC, G-YH, W-MC), National Yang-Ming University; Therapeutical and Research Center of Musculoskeletal Tumor (C-YL, C-CY, H-JY, C-YS, T-CC, P-KW, C-FC, PC-HC, H-THW, H-JC, G-YH, W-MC), Department of Orthopedics; Division of Medical Oncology (C-CY, T-CC), Department of Oncology, Taipei Veterans General Hospital; Department of Life Science (H-JY, G-YH), National Taiwan Normal University; Division of Radiation Oncology (C-YS), Department of Oncology; Department of Orthopedics (P-KW, C-FC); Department of Pathology (PC-HC); Department of Radiology (H-THW, H-JC), Taipei Veterans General Hospital; National Defense Medical Center (H-JC), Taipei; Department of Pediatrics (C-CC), Taipei Veterans General Hospital Hsinchu Branch, Hsinchu; and Rehabilitation and Technical Aid Center (W-MC), Taipei Veterans General Hospital, Taipei, Taiwan.
Chueh-Chuan Yen
Hsiu-Ju Yen
Cheng-Ying Shiau
Ta-Chung Chao
Po-Kuei Wu
Cheng-Fong Chen
Paul Chih-Hsueh Chen
Hung-Ta Hondar Wu
Hong-Jen Chiou
Chao-Chun Chen
Giun-Yi Hung
Wei-Ming Chen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To identify the prognostic factors and long-term outcome of the Ewing sarcoma family of tumors (ESFT), data on 50 patients with ESFT treated at Taipei Veterans General Hospital between February 1991 and March 2014 were retrospectively considered. The influence of patient demographics, tumor features, and clinical and therapeutic parameters on overall survival (OS) and progression-free survival (PFS) rates were assessed. The results revealed that 21 of the 50 patients (42%) were metastatic at diagnosis. The median follow-up time was 1.8 years. The 5-year OS and PFS for patients who were nonmetastatic were 61.6% and 55.5%, respectively, and 18.8% and 15.4% for patients who were metastatic, respectively. The key adverse prognostic factor was metastasis at diagnosis. Radiotherapy for local control was associated with improved PFS. The high rate of primary metastasis and poorer outcomes of nonmetastatic ESFT compared with results from Western studies, along with previously reported low rates of ESFT in Taiwanese people, suggest that genetic factors play a role in the pathogenesis of ESFT and chemotherapy pharmacokinetics and pharmacodynamics. Radiotherapy in local treatment should be considered more aggressively in Taiwanese patients with ESFT.

Indexed as

AdolescentAdultAgedAge FactorsBone NeoplasmsFemaleHumansMaleMargins of ExcisionMiddle AgedNeoplasm MetastasisPrognosisProportional Hazards ModelsRetrospective StudiesSarcoma, EwingSex Factors

Identifiers

PMID27258529
PMCPMC4900737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.