ArticleJournal of Alzheimer's disease : JAD2016
Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice.
Article in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Characterization of theMolecules (Basel, Switzerland) · 2024Trial
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- Bioactive Compounds of Green Phenolic Extracts Obtained via Microwave-Assisted Extraction ofMolecules (Basel, Switzerland) · 2024Article
- Beneficial Effects ofAntioxidants (Basel, Switzerland) · 2024Article
- Extracts ofInternational journal of molecular sciences · 2024Article
- Pomegranate peel, chokeberry leaves and Ironwort extract as novel natural inhibitors of amylin aggregation and cellular toxicity in pancreatic β cells.Biophysical chemistry · 2024Article
- Antioxidant and Antitumor Potential of Micropropagated Balkan EndemicPlants (Basel, Switzerland) · 2023Article
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- Phytochemical Composition and Cytoprotective Properties of the EndemicPharmaceuticals (Basel, Switzerland) · 2022Article
- Neuroprotective Herbs for the Management of Alzheimer's Disease.Biomolecules · 2021Review
- A Comparison Study on Traditional Mixtures of Herbal Teas Used in Eastern Mediterranean Area.Frontiers in pharmacology · 2021Article
- Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia.Journal of Alzheimer's disease : JAD · 2021Article
- Behavioral and Neurochemical Effects of Extra Virgin Olive Oil Total Phenolic Content andMolecules (Basel, Switzerland) · 2020Article
- Polyphenols and Other Bioactive Compounds ofMolecules (Basel, Switzerland) · 2020Review
- Traditionally UsedFrontiers in pharmacology · 2020Article
- Genus Sideritis, section Empedoclia in southeastern Europe and Turkey - studies in ethnopharmacology and recent progress of biological activities.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Review
- Anti-Inflammatory Activity of A Polyphenolic Extract fromInternational journal of molecular sciences · 2019Article
- Therapeutic Effects of Natural Drugs on Alzheimer's Disease.Frontiers in pharmacology · 2019Review
- Article
- Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review.Pain research & management · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nowadays, Alzheimer's disease is the most prevalent epiphenomenon of the aging population. Although soluble amyloid-β (Aβ) species (monomers, oligomers) are recognized triggers of the disease, no therapeutic approach is able to stop it. Herbal medicines are used to treat different diseases in many regions of the world. On the Balkan Peninsula, at the eastern Mediterranean Sea, and adjacent regions, Sideritis species are used as traditional medicine to prevent age-related problems in elderly. To evaluate this traditional knowledge in controlled experiments, we tested extracts of two commonly used Sideritis species, Sideritis euboea and Sideritis scardica, with regard to their effects on cognition in APP-transgenic and aged, non-transgenic C57Bl/6 mice. Additionally, histomorphological and biochemical changes associated with Aβ deposition and treatment were assessed. We found that daily oral treatment with Sideritis spp. extracts highly enhanced cognition in aged, non-transgenic as well as in APP-transgenic mice, an effect that was even more pronounced when extracts of both species were applied in combination. The treatment strongly reduced Aβ42 load in APP-transgenic mice, accompanied by increased phagocytic activity of microglia, and increased expression of the α-secretase ADAM10. Moreover, the treatment was able to fully rescue neuronal loss of APP-transgenic mice to normal levels as seen in non-transgenic controls. Having the traditional knowledge in mind, our results imply that treatment with Sideritis spp. extracts might be a potent, well-tolerated option for treating symptoms of cognitive impairment in elderly and with regard to Alzheimer's disease by affecting its most prominent hallmarks: Aβ pathology and cognitive decline.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.