Evidence map›Paper›PMID 27258316›Full record

ReviewVaccines2016

Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems.

Ru Wen, Afoma C Umeano, Lily Francis, Nivita Sharma, Smanla Tundup, Shanta Dhar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vaccines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Nanoparticle systems for cancer vaccine.Nanomedicine (London, England) · 2019
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ru WenNanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. soso2012@uga.edu.
Afoma C UmeanoNanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. aumeano@uga.edu.
Lily FrancisNanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. lgf39148@uga.edu.
Nivita SharmaNanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. nivita.sharma97@uga.edu.
Smanla TundupSchool of Medicine, Department of Pulmonary and Critical Care, University of Virginia, Charlottesville, WV 22908, USA. st2vk@virginia.edu.
Shanta DharNanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA. shanta@uga.edu.

Funding

Combined Nanoparticle and Neural Stem Cell Therapies in a Pig Model of StrokeR01NS093314 · NINDS · UNIVERSITY OF GEORGIA · PI WEST, FRANKLIN D · 2015 to 2019
$2.4M
A high-density lipoprotein-based theranostic nanoparticle platform for atherosclerosisR56HL121392 · NHLBI · UNIVERSITY OF GEORGIA · PI DHAR, SHANTA · 2014 to 2014
$364k
NHLBI NIH HHS R56 HL121392NINDS NIH HHS R01 NS093314
6 · The paper itself

Abstract

Vaccination is one of the most popular technologies in disease prevention and eradication. It is promising to improve immunization efficiency by using vectors and/or adjuvant delivery systems. Nanoparticle (NP)-based delivery systems have attracted increasing interest due to enhancement of antigen uptake via prevention of vaccine degradation in the biological environment and the intrinsic immune-stimulatory properties of the materials. Mitochondria play paramount roles in cell life and death and are promising targets for vaccine delivery systems to effectively induce immune responses. In this review, we focus on NPs-based delivery systems with surfaces that can be manipulated by using mitochondria targeting moieties for intervention in health and disease.

Indexed as

antigen deliverymitochondria targetingnanoparticlesvaccine

Identifiers

PMID27258316
PMCPMC4931635

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.