Evidence map›Paper›PMID 27258269›Full record

ReviewInternational journal of molecular sciences2016

Review on Graph Clustering and Subgraph Similarity Based Analysis of Neurological Disorders.

Jaya Thomas, Dongmin Seo, Lee Sael

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jaya ThomasDepartment of Computer Science, Stony Brook University, Stony Brook, NY 11794, USA. jaya.thomas@sunykorea.ac.kr.
Dongmin SeoKorea Institute of Science and Technology Information, 245 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea. dmseo@kisti.re.kr.
Lee SaelDepartment of Computer Science, Stony Brook University, Stony Brook, NY 11794, USA. sael@cs.stonybrook.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How can complex relationships among molecular or clinico-pathological entities of neurological disorders be represented and analyzed? Graphs seem to be the current answer to the question no matter the type of information: molecular data, brain images or neural signals. We review a wide spectrum of graph representation and graph analysis methods and their application in the study of both the genomic level and the phenotypic level of the neurological disorder. We find numerous research works that create, process and analyze graphs formed from one or a few data types to gain an understanding of specific aspects of the neurological disorders. Furthermore, with the increasing number of data of various types becoming available for neurological disorders, we find that integrative analysis approaches that combine several types of data are being recognized as a way to gain a global understanding of the diseases. Although there are still not many integrative analyses of graphs due to the complexity in analysis, multi-layer graph analysis is a promising framework that can incorporate various data types. We describe and discuss the benefits of the multi-layer graph framework for studies of neurological disease.

Indexed as

Cluster AnalysisModels, BiologicalAnimalsBrainComputer SimulationGene Regulatory NetworksHumansMetabolic Networks and PathwaysNerve NetNervous System DiseasesNeural PathwaysProtein Interaction MapsSignal Transductionbiological networkfunctional brain networkgraph clusteringgraph similaritymulti-layer graphsneurological diseasestructural brain network

Identifiers

PMID27258269
PMCPMC4926396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.