Evidence map›Paper›PMID 27258254›Full record

ArticleInternational journal of molecular sciences2016

Longitudinal Effects of Embryonic Exposure to Cocaine on Morphology, Cardiovascular Physiology, and Behavior in Zebrafish.

Eric J Mersereau, Cody A Boyle, Shelby Poitra, Ana Espinoza, Joclyn Seiler, Robert Longie, Lisa Delvo, Megan Szarkowski, Joshua Maliske, Sarah Chalmers and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Eric J MersereauBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. emersereau93@midwestern.edu.
Cody A BoyleBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. cody.boyle.1@und.edu.
Shelby PoitraBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. Shelby.poitra@gmail.com.
Ana EspinozaDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA. amespinoza@email.arizona.edu.
Joclyn SeilerBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. joclyn.seiler.2@my.und.edu.
Robert LongieBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. Robert.a.longie@gmail.com.
Lisa DelvoBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. lisadelvo@gmail.com.
Megan SzarkowskiBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. meganszarkowski@gmail.com.
Joshua MaliskeBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. josh.k.maliske@gmail.com.
Sarah ChalmersBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. Sarah.J.Chalmers@osfhealthcare.org.
Diane C DarlandBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. diane.darland@und.edu.
Tristan DarlandBiology Department, University of North Dakota, 10 Cornell Street, Grand Forks, ND 58202, USA. tristan.darland@email.und.edu.
Cornell University · USUniversity of North Dakota · USUniversity of Arizona · US

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
WORKSHOPS AND EVALUATIONP20RR016471 · NCRR · UNIVERSITY OF NORTH DAKOTA · PI DELORME, EUGENE L. · 2001 to 2011
$31.7M
NCRR NIH HHS P20 RR016471NIGMS NIH HHS P20 GM103442
6 · The paper itself

Abstract

A sizeable portion of the societal drain from cocaine abuse results from the complications of in utero drug exposure. Because of challenges in using humans and mammalian model organisms as test subjects, much debate remains about the impact of in utero cocaine exposure. Zebrafish offer a number of advantages as a model in longitudinal toxicology studies and are quite sensitive physiologically and behaviorally to cocaine. In this study, we have used zebrafish to model the effects of embryonic pre-exposure to cocaine on development and on subsequent cardiovascular physiology and cocaine-induced conditioned place preference (CPP) in longitudinal adults. Larval fish showed a progressive decrease in telencephalic size with increased doses of cocaine. These treated larvae also showed a dose dependent response in heart rate that persisted 24 h after drug cessation. Embryonic cocaine exposure had little effect on overall health of longitudinal adults, but subtle changes in cardiovascular physiology were seen including decreased sensitivity to isoproterenol and increased sensitivity to cocaine. These longitudinal adult fish also showed an embryonic dose-dependent change in CPP behavior, suggesting an increased sensitivity. These studies clearly show that pre-exposure during embryonic development affects subsequent cocaine sensitivity in longitudinal adults.

Indexed as

AnimalsBehavior, AnimalCardiovascular Physiological PhenomenaCocaineDose-Response Relationship, DrugEmbryo, NonmammalianZebrafishCocaineand behaviorcardiovascular physiologycocainezebrafish

Identifiers

PMID27258254
PMCPMC4926381
OpenAlexW2417170185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.