ArticleDiabetes technology & therapeutics2016
Association of HbA1c to BOLUS Scores Among Youths with Type 1 Diabetes.
Article in Diabetes technology & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06390371 (Spotlight AQ Randomized Controlled Trial of the Spotlight AQ Survey Platform to Evaluate Its' Efficacy and Applicability in a Clinic Setting.), which is not on this map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Spotlight AQ Randomized Controlled Trial of the Spotlight AQ Survey Platform to Evaluate Its' Efficacy and Applicability in a Clinic Setting.
Who cites it
9 citing papers in PubMed.
- Pump It Up! A randomized clinical trial to optimize insulin pump self-management behaviors in adolescents with type 1 diabetes.Contemporary clinical trials · 2021Trial
- Establishment of a Diabetes-Tailored Data Intelligence Platform Enhances Clinical Care, Enables Risk-Based Monitoring, and Facilitates Population-Health-Based Approaches at a Pediatric Diabetes Network.Journal of diabetes science and technology · 2025Article
- Novel predictors of daily fluctuations in glycemia and self-management in adolescents and young adults with type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2022Article
- Real-World Use of a New Hybrid Closed Loop Improves Glycemic Control in Youth with Type 1 Diabetes.Diabetes technology & therapeutics · 2021Article
- A Digital Health Intervention (SweetGoals) for Young Adults With Type 1 Diabetes: Protocol for a Factorial Randomized Trial.JMIR research protocols · 2021Article
- Six-Month Effectiveness of AdvancedFrontiers in endocrinology · 2021Article
- Mealtime insulin bolus adherence and glycemic control in adolescents on insulin pump therapy.European journal of pediatrics · 2018Article
- Hope and mealtime insulin boluses are associated with depressive symptoms and glycemic control in youth with type 1 diabetes mellitus.Pediatric diabetes · 2018Article
- Frequency of Missed Insulin Boluses in Type 1 Diabetes and Its Impact on Diabetes Control.Diabetes technology & therapeutics · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundFrequency of mealtime insulin bolusing (BOLUS) is a promising new objective assessment of adherence in youths with type 1 diabetes (T1D). As further confirmation of the validity of BOLUS, we compare the associations of glycated hemoglobin (HbA1c) values of T1D youths with the original scoring of BOLUS and two alternative scoring procedures: mean mealtime boluses within a 2-h meal window (2h-BOLUS) and total daily frequency of boluses (TOTAL-BOLUS). In addition, we assess HbA1c associations of these three procedures, including interaction terms for mealtime boluses plus correction boluses. SUBJECTS AND
methodsBlood glucose meter data, insulin pump records, and HbA1c levels were collected from a combined clinical and research database for a random sample of 100 youths (mean age, 12.7 ± 4.6 years). Youths' pump records were scored using the published methodology and alternative procedures for evaluating insulin use.
resultsYouths' BOLUS, TOTAL-BOLUS, and mealtime boluses within a 2-h meal window (2h-BOLUS) scores are independently associated with youths' HbA1c level; all measures demonstrated stronger associations with youths' HbA1c than did frequency of glucose monitoring. The strongest association was between youths' BOLUS score and their HbA1c level. In multiple regression analyses, youths' BOLUS score better explains the variations in HbA1c levels than either youths' 2h-BOLUS or TOTAL-BOLUS scores. When combined with BOLUS in the same relationships, 2h-BOLUS and TOTAL-BOLUS were not found to have statistically significant coefficients. None of the bivariate relationships of HbA1c and interaction terms of mealtime and correction boluses was significant.
conclusionsThe original method for calculating BOLUS appears superior to alternative scoring methods in its association with youths' HbA1c levels.
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