ReviewAnesthesia and analgesia2016
Opioid-induced Hallucinations: A Review of the Literature, Pathophysiology, Diagnosis, and Treatment.
Review in Anesthesia and analgesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Modulatory effect of opioid administration on the activity of cholinesterase enzyme: a systematic review of mice/rat models.Environmental science and pollution research international · 2021Pooled it
- Tramadol-associated hallucinations: a systematic review and narrative synthesis of their pathophysiology, diagnosis, and treatment.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2020Pooled it
- The Diagnostic Spectrum of Sexual Hallucinations.Harvard review of psychiatryPooled it
- Explainable drug side effect prediction in central neural system via biologically informed graph neural network.Translational psychiatry · 2026Article
- Early Use of Fentanyl Increases Risk of Delirium in Patients Transfer to the intensive Care Unit After Cardiac Surgery Immediately: A Target Trial Emulation.Journal of evidence-based medicine · 2026Article
- Compartment Syndrome Secondary to Envenomation by Bothrops asper: Anesthetic Challenges.Cureus · 2026Article
- Opioid dose, duration, and risk of use disorder in Medicaid patients with musculoskeletal pain.Pain medicine (Malden, Mass.) · 2026Article
- Perceptual Discrepancies of Opioid Analgesics and Psychotropic Drugs: A Cross-Sectional Study of Korean Patients and Physicians.Journal of clinical medicine · 2025Article
- Opioid-Induced Myoclonus During Premedication in Two Dogs With Hydrocephalus Proactively Managed With Antiepileptic Medications.Veterinary medicine and science · 2025Article
- Hydrocodone-Induced Delirium in an Otherwise Healthy 20-Year-Old Male.Ochsner journal · 2025Article
- Opioid-Induced Hallucinations: A Case Report.Cureus · 2024Article
- Drug-induced musical hallucination.Frontiers in pharmacology · 2024Review
- Delirium in critical illness: clinical manifestations, outcomes, and management.Intensive care medicine · 2021Review
- Article
- Pancreas Cancer-Associated Pain Management.The oncologist · 2021Review
- Lessons from the Analysis of a Retrospective Cohort of Patients Who Underwent Large Open Abdominal Surgery Under Total Intravenous Opioid-Free Anesthesia.Drugs - real world outcomes · 2021Article
- Article
- The Pharmacology of Visual Hallucinations in Synucleinopathies.Frontiers in pharmacology · 2019Review
- Frequency, Outcomes, and Associated Factors for Opioid-Induced Neurotoxicity in Patients with Advanced Cancer Receiving Opioids in Inpatient Palliative Care.Journal of palliative medicine · 2018Article
- Safety implications of concomitant administration of antidepressants and opioid analgesics in surgical patients.Expert opinion on drug safetyObservational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Despite their association with multiple adverse effects, opioid prescription continues to increase. Opioid-induced hallucination is an uncommon yet significant adverse effect of opioid treatment. The practitioner may encounter patient reluctance to volunteer the occurrence of this phenomenon because of fears of being judged mentally unsound. The majority of the literature concerning opioid-induced hallucinations arises from treatment during end-of-life care and cancer pain. Because the rate of opioid prescriptions continues to increase in the population, the rate of opioid-associated hallucinations may also conceivably increase. With a forecasted increase in the patient-to-physician ratio, opioid therapy is predicted to be provided by practitioners of varying backgrounds and medical specialties. Hence, knowledge of the pharmacology and potential adverse effects of these agents is required. This review seeks to increase awareness of this potential complication through a discussion of the literature, potential mechanisms of action, diagnosis, and treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.