SynthesisPloS one2016
Meta-Analysis of the Effect of Bowel Preparation on Adenoma Detection: Early Adenomas Affected Stronger than Advanced Adenomas.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Percentage Visualized Mucosa as a Marker for the Quality of Colonoscopy
Evaluation of a Modified Bowel Preparation Regimen in Cirrhotic Patients Undergoing Colonoscopy: a Multicentre Randomized Controlled Trial
Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Efficacy and safety of linaclotide plus polyethylene glycol for bowel preparation before colonoscopy in elderly Chinese patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Combined linaclotide and polyethylene glycol electrolyte for colonoscopy preparation: a network meta-analysis of 14 randomized controlled trials.International journal of colorectal disease · 2025Pooled it
- Oral sulfate solution benefits polyp and adenoma detection during colonoscopy: Meta-analysis of randomized controlled trials.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2022Pooled it
- Advanced intestinal regulation improves bowel preparation quality in patients with constipation: A systematic review and network meta-analysis.Frontiers in pharmacology · 2022Pooled it
- Efficacy of 1 L PEG Ascorbate vs Sodium Picosulfate With Magnesium Citrate Bowel Preparations for Capsule Colonoscopy and Pan-Intestinal Capsule Endoscopy: A Prospective Study.Clinical and translational gastroenterology · 2026Trial
- Evaluation of the efficacy of polyethylene glycol in combination with different doses of linaclotide in a fractionated bowel preparation for colonoscopy: a prospective randomized controlled study.International journal of colorectal disease · 2024Trial
- Prevalence of missed lesions in patients with inadequate bowel preparation through a very early repeat colonoscopy.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2022Trial
- Can a 1-day clear liquid diet with a split -dose polyethylene glycol overcome conventional practice patterns during the preparation for screening colonoscopy?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Trial
- Article
- Feasibility of a Stool State Check App Using AI During Bowel Preparation Before Colonoscopy: Multicenter Prospective Study (SCAN Study).JMIR mHealth and uHealth · 2026Observational
- To what extent can bowel preparation quality be considered "adequate"?: a systematic review and meta-analysis.Clinical endoscopy · 2026Article
- A Machine Learning-Based Clinical Tool for Predicting Inadequate Bowel Preparation: Development and Validation.Clinical and translational gastroenterology · 2026Article
- Comparison of the Effectiveness of Three Different Combinations for Colonoscopy Preparation: A Multicenter Randomized Clinical Trial.Diagnostics (Basel, Switzerland) · 2026Article
- Knowledge, attitudes, and practices of nurses regarding bowel preparation for colonoscopy: a structural equation modeling analysis.Frontiers in public health · 2026Article
- Compliance With Bowel Preparation and Its Influencing Factors in Patients Undergoing Colonoscopy: Cross-Sectional Study.Interactive journal of medical research · 2025Article
- Combating Post-colonoscopy Colorectal Cancer: Insight from the Trials and Cohort Studies.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Review
- A Prospective Randomized Study to Predict Bowel Preparation Quality Prior to Colonoscopy: Comparison of Two Stool Collection Methods for the Objective Assessment of Final Rectal Effluent Clarity.Diagnostics (Basel, Switzerland) · 2025Article
- Association of distal adenoma and hyperplastic polyp characteristics with long-term proximal colon cancer risk: a secondary, observational analysis of data from the UK Flexible Sigmoidoscopy Screening Trial.BMJ open gastroenterology · 2025Observational
- Impact of Bowel Preparation Type on Colonoscopy Quality and Adenoma Detection: A Comparative Study.Cureus · 2025Article
- Think-Aloud Testing of a Companion App for Colonoscopy Examinations: Usability Study.JMIR human factors · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsLow-quality bowel preparation reduces efficacy of colonoscopy. We aimed to summarize effects of bowel preparation on detection of adenomas, advanced adenomas and colorectal cancer.
methodsA systematic literature search was performed regarding detection of colonic lesions after normal and low-quality bowel preparation. Reported bowel preparation quality was transformed to the Aronchick scale with its qualities "excellent", "good", "fair", "poor", and "insufficient" or "optimal" (good/excellent), "suboptimal" (fair/poor/insufficient), "adequate" (good/excellent/fair) and "inadequate" (poor/insufficient). We identified two types of studies: i) Comparative studies, directly comparing lesion detection according to bowel preparation quality, and ii) repeat colonoscopy studies, reporting results of a second colonoscopy after previous low-quality preparation.
resultsThe detection of early adenomas was reduced with inadequate vs. adequate bowel preparation (Odds Ratio (OR) 0.53, CI: 0.46-0.62, p<0.001). The advanced adenomas were affected less in comparison (0.74, CI: 0.62-0.87, p<0.001). The large number of subjects considered in the present meta-analysis resulted in smaller confidence intervals compared to earlier studies. Classifying the bowel-preparation quality as suboptimal vs. optimal led to the same qualitative conclusion (OR: 0.81, CI: 0.74-0.89, p<0.001 for early adenomas, OR: 0.94, CI: 0.87-1.01, n.s. for advanced adenomas). Bowel preparation was equally important for right-sided/ flat/ serrated vs. other lesions in most observational studies but more relevant in some repeat colonoscopy studies; data regarding carcinoma detection were insufficient.
conclusionInadequate bowel preparation affects detection of early colonic lesions stronger than advanced lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.