Evidence map›Paper›PMID 27257909›Full record

ArticlePloS one2016

Anthrax Toxin-Expressing Bacillus cereus Isolated from an Anthrax-Like Eschar.

Chung K Marston, Hisham Ibrahim, Philip Lee, George Churchwell, Megan Gumke, Danielle Stanek, Jay E Gee, Anne E Boyer, Maribel Gallegos-Candela, John R Barr and 5 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 56 citations in OpenAlex.

  1. TrackingACS omega · 2026
    Review
  2. Welder's Anthrax Treated with Obiltoxaximab - Louisiana, 2024.MMWR. Morbidity and mortality weekly report · 2026
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  3. Review
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  9. Anthrax revisited: how assessing the unpredictable can improve biosecurity.Frontiers in bioengineering and biotechnology · 2023
    Article
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  14. Article
  15. Article
  16. What Is Anthrax?Pathogens (Basel, Switzerland) · 2022
    Article
  17. Review
  18. Ecological Niche Model ofPathogens (Basel, Switzerland) · 2022
    Article
  19. Article
  20. TaqMan Assays for Simultaneous Detection ofPathogens (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Chung K MarstonNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Hisham IbrahimVillages Regional Hospital, Lady Lake, FL, United States of America.
Philip LeeBureau of Public Health Laboratories, Florida Department of Health, Jacksonville, FL, United States of America.
George ChurchwellBureau of Public Health Laboratories, Florida Department of Health, Jacksonville, FL, United States of America.
Megan GumkeBureau of Epidemiology, Florida Department of Health, Tallahassee, FL, United States of America.
Danielle StanekBureau of Epidemiology, Florida Department of Health, Tallahassee, FL, United States of America.
Jay E GeeNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Anne E BoyerNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Maribel Gallegos-CandelaNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
John R BarrNational Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Han LiNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Darbi BoulayNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Li CroninNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Conrad P QuinnNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Alex R HoffmasterNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Florida Department of Health · USCenters for Disease Control and Prevention · USNational Center for Environmental Health · USNational Center for Immunization and Respiratory Diseases · USChildren’s Village · USNational Center for Emerging and Zoonotic Infectious Diseases · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

Bacillus cereus isolates have been described harboring Bacillus anthracis toxin genes, most notably B. cereus G9241, and capable of causing severe and fatal pneumonias. This report describes the characterization of a B. cereus isolate, BcFL2013, associated with a naturally occurring cutaneous lesion resembling an anthrax eschar. Similar to G9241, BcFL2013 is positive for the B. anthracis pXO1 toxin genes, has a multi-locus sequence type of 78, and a pagA sequence type of 9. Whole genome sequencing confirms the similarity to G9241. In addition to the chromosome having an average nucleotide identity of 99.98% when compared to G9241, BcFL2013 harbors three plasmids with varying homology to the G9241 plasmids (pBCXO1, pBC210 and pBFH_1). This is also the first report to include serologic testing of patient specimens associated with this type of B. cereus infection which resulted in the detection of anthrax lethal factor toxemia, a quantifiable serum antibody response to protective antigen (PA), and lethal toxin neutralization activity.

Indexed as

AgedAnthraxAntigens, BacterialBacillus cereusBacterial ToxinsHumansMaleanthrax toxinAntigens, BacterialBacterial Toxins

Identifiers

PMID27257909
PMCPMC4892579
OpenAlexW2419153323

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.