ArticlePloS one2016
Frailty as a Predictor of Acute Kidney Injury in Hospitalized Elderly Patients: A Single Center, Retrospective Cohort Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Impact of Frailty on Activities of Daily Living in Hospitalized Older Adults: A Systematic Review and Meta-Analysis.Geriatrics & gerontology international · 2026Pooled it
- Incidence, severity, risk factors and outcomes of acute kidney injury in older adults: systematic review and meta-analysis.Journal of nephrology · 2022Pooled it
- Association of acute kidney injury with frailty in elderly population: a systematic review and meta-analysis.Renal failure · 2019Pooled it
- Pooled it
- The Influence of Frailty on Total Hip Arthroplasty Outcomes: A Propensity-Matched Study of 90,660 Patients Using the Modified Frailty Index.Journal of clinical medicine · 2026Article
- Higher hospital frailty risk score is predictive of 90-day readmission after minimally invasive colorectal cancer surgery: a national readmission database analysis.American journal of cancer research · 2025Article
- National clinical and financial outcomes associated with acute kidney injury following esophagectomy for cancer.PloS one · 2024Article
- Advances of perioperative acute kidney injury in elderly patients undergoing non-cardiac surgery.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Review
- Article
- Association of serum potassium level with early and late mortality in very elderly patients with acute kidney injury.Journal of intensive medicine · 2022Article
- Association Between the Severity of Early Acute Kidney Injury and Subsequent in-Hospital Complications and 90-Day Mortality in Geriatric Patients Receiving Invasive Mechanical Ventilation.Risk management and healthcare policy · 2022Article
- Application of Machine Learning Algorithms to Predict Acute Kidney Injury in Elderly Orthopedic Postoperative Patients.Clinical interventions in aging · 2022Article
- Clinical Knowledge Supported Acute Kidney Injury (AKI) Risk Assessment Model for Elderly Patients.International journal of environmental research and public health · 2021Article
- Serum Sodium Levels Predict Mortality in Elderly Acute Kidney Injury Patients: A Retrospective Observational Study.International journal of general medicine · 2021Article
- Severity of frailty as a significant predictor of mortality for hemodialysis patients: a prospective study in China.International journal of medical sciences · 2021Observational
- Exploration of the Relationship Among Key Risk Factors of Acute Kidney Injury for Elderly Patients Considering Covid-19.Frontiers in medicine · 2021Article
- Clinical features, risk factors, and clinical burden of acute kidney injury in older adults.Renal failure · 2020Observational
- Mortality in non-elderly septic patients was increased with hypothermia and decreased with fever while mortality in elderly patients was not associated with body temperature: beware of some confounders!Critical care (London, England) · 2020Article
- Continuous renal replacement therapy in elderly with acute kidney injury.The Korean journal of internal medicine · 2020Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElderly patients have an increased risk for acute kidney injury (AKI). However, few studies have reported on predictors for AKI in geriatric patients. Therefore, we aimed at determining the effect of frailty as a predictor of AKI.
methodsWe retrospectively enrolled 533 hospitalized elderly patients (aged ≥ 65 years) who had their creatinine levels measured (≥ 1 measurement) during admission for a period of 1 year (2013) and conducted a comprehensive geriatric assessment (CGA) within 1 year before the index hospitalization. We examined five variables (activity of daily living [ADL] and instrumental ADL dependence, dementia, nutrition, and polypharmacy) from CGA. We categorized the patients into 3 groups according to the tertile of aggregate frailty scores: Group 1, score 1-2; Group 2, score 3-4; Group 3, score 5-8).
resultsFifty-four patients (10.1%) developed AKI (median duration, 4 days). The frailest group (Group 3) showed an increased risk of AKI as compared to Group 1, (hazard ratio [HR] = 3.536, P = 0.002). We found that discriminatory accuracy for AKI improved with the addition of the tertile of aggregate frailty score to covariates (area under the receiver operator characteristics curves [AUROC] 0.641, AUROC 0.739, P = 0.004). Forty-six patients (8.6%) were transferred to nursing facilities and 477 patients (89.5%) were discharged home. The overall 90-day and 1-year mortality for elderly inpatients were 7.9% and 26.3%. The frailest group also demonstrated an increased risk of discharge to nursing facilities, and 90-day and 1-year mortality as compared to Group 1, independent of AKI severity (nursing facilities: odd ratio = 4.843, P = 0.002; 90-day mortality: HR = 6.555, P = 0.002; 1-year mortality: HR = 3.249, P = 0.001).
conclusionsWe found that frailty may independently predict the development of AKI and adverse outcomes in geriatric inpatients.
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