ArticleMolecular medicine (Cambridge, Mass.)2016
Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach.
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Article in Molecular medicine (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
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Who cites it
40 citing papers in PubMed, 73 citations in OpenAlex.
- Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, HGeroScience · 2024Article
- Role of hydrogen sulfide in health and disease.MedComm · 2024Review
- Recent advances in the role of endogenous hydrogen sulphide in cancer cells.Cell proliferation · 2023Review
- Role of Cystathionine β-Synthase and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics of Murine Breast Cancer Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies.Redox biology · 2023Review
- Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells.Frontiers in oncology · 2023Article
- Reactive sulfur species and their significance in health and disease.Bioscience reports · 2022Review
- HCellular and molecular life sciences : CMLS · 2022Article
- Emerging roles of cystathionine β-synthase in various forms of cancer.Redox biology · 2022Review
- The CBS-HBritish journal of cancer · 2022Article
- Methods for Suppressing Hydrogen Sulfide in Biological Systems.Antioxidants & redox signaling · 2022Review
- Hydrogen Sulfide Actions in the Vasculature.Comprehensive Physiology · 2021Article
- Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis.Journal for immunotherapy of cancer · 2021Article
- Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept.Biomolecules · 2021Article
- Therapeutic potential of endogenous hydrogen sulfide inhibition in breast cancer (Review).Oncology reports · 2021Review
- Cysteine metabolic circuitries: druggable targets in cancer.British journal of cancer · 2021Review
- Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia.Signal transduction and targeted therapy · 2021Article
- Review
- Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
26 authors at 1 institution in 1 country.
Celia Chao *Department of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
John R Zatarain *Department of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Ye Ding *Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America
Ciro ColettaDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Amy A MrazekDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Nadiya DruzhynaDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Paul JohnsonDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Haiying ChenDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America
Judy L HellmichDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Antonia AsimakopoulouDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Kazunori YanagiDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Gabor OlahDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Petra SzoleczkyDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Gabor TöröDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Fredrick J BohanonDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Minal CheemaDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Rachel LewisDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
David EckelbargerDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Akbar AhmadDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Katalin MódisDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Ashley UntereinerDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Bartosz SzczesnyDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Andreas PapapetropoulosDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
Jia ZhouDepartment of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America
Mark R HellmichDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas, United States of America
Csaba SzaboDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States of America
The University of Texas Medical Branch at Galveston · US
Funding
UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0MSURGICAL TRAINING IN GASTROINTESTINAL ENDOCRINOLOGYT32DK007639 · NIDDK · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI RADHAKRISHNAN, RAVI S. · 1992 to 2022
$3.6MRole of Hydrogen Sulfide in Colorectal TumorsR01CA175803 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HELLMICH, MARK R, SZABO, CSABA · 2014 to 2018
$1.5MNCATS NIH HHS UL1 TR001439NCI NIH HHS R01 CA175803NIDDK NIH HHS T32 DK007639
Abstract
Colon cancer cells contain high levels of cystathionine-beta-synthase (CBS). Its product, hydrogen sulfide (H
Indexed as
cell proliferationcystathionine-beta-synthasedrug developmentHydrogen sulfidetumor growth
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.