Evidence map›Paper›PMID 27257676›Full record

SynthesisPloS one2016

Antibioprophylaxis in Prevention of Endophthalmitis in Intravitreal Injection: A Systematic Review and Meta-Analysis.

Cédric Benoist d'Azy, Bruno Pereira, Geraldine Naughton, Frédéric Chiambaretta, Frédéric Dutheil

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 16 syntheses or guidelines pooled it.

  1. Pooled it
  2. Myopia and Near Work: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023
    Pooled it
  3. Efficacy of treatments for neurotrophic keratopathy: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Pooled it
  4. Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
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  6. Effects of a Short Daytime Nap on the Cognitive Performance: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  7. Breastfeeding after Returning to Work: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
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  17. Trial
  18. Article
  19. Article
  20. Pheochromocytoma and heart rate variability: a systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cédric Benoist d'AzyUniversity Hospital of Clermont-Ferrand (CHU), Ophthalmology, Clermont-Ferrand, France.
Bruno PereiraUniversity Hospital of Clermont-Ferrand (CHU), Clinical Research Direction, Clermont-Ferrand, France.
Geraldine NaughtonAustralian Catholic University, Faculty of Health, Melbourne, Victoria, Australia.
Frédéric ChiambarettaUniversity Hospital of Clermont-Ferrand (CHU), Ophthalmology, Clermont-Ferrand, France.
Frédéric DutheilUniversity Hospital of Clermont-Ferrand (CHU), Preventive and Occupational Medicine, Clermont-Ferrand, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite endophthalmitis being the most feared complication, antibioprophylaxis remains controversial in intravitreal injections. Therefore, we conducted a systematic review and meta-analysis on the effects of antibioprophylaxis in intravitreal injections in the prevention of endophthalmitis. The PubMed, Cochrane Library, Embase and Science Direct databases were searched for studies comparing groups with and without antibiotics in intravitreal injection, with the use of the following keywords: "antibiotic*", "endophthalmitis" and "intravitreal injection*". To be included, studies needed to specify number of participants and number of endophthalmitis within each group (with and without antibiotics). We conducted meta-analysis on the prevalence of clinical endophthalmitis including both culture-proven and culture negative samples. Nine studies were included. A total of 88 incidences of endophthalmitis were reported from 174,159 injections (0.051% i.e., one incidence of endophthalmitis for 1979 injections). Specifically, 59 incidences of endophthalmitis were reported from 113,530 injections in the group with antibiotics (0.052% or one incidence of endophthalmitis for 1924 injections) and 29 incidences of endophthalmitis from 60,633 injections in the group without antibiotics (0.048% or one endophthalmitis for 2091 injections). Our meta-analysis did not report a significant difference in the prevalence of clinical endophthalimitis between the two groups with and without topical antibiotics: the odds ratio of clinical endophthalimitis was 0.804 (CI95% 0.384-1.682, p = 0.56) for the antibiotic group compared with the group without antibiotics. In conclusion, we performed the first large meta-analysis demonstrating that antibioprophylaxis is not required in intravitreal injections. Strict rules of asepsis remain the only evidence-based prophylaxis of endophthalmitis. The results support initiatives to reduce the global threat of resistance to antibiotics.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisEndophthalmitisEye Infections, BacterialHumansIntravitreal InjectionsAnti-Bacterial Agents

Identifiers

PMID27257676
PMCPMC4892688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.