ArticleeNeuro
Vitamin D3: A Role in Dopamine Circuit Regulation, Diet-Induced Obesity, and Drug Consumption.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
- Efficacy of high-dose vs. low-dose vitamin D₃ supplementation in children with chronic tic disorders: a randomized controlled trial.Nutrition journal · 2025Trial
- Vitamin D's Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [Biological psychiatry · 2025Trial
- Associations Between Vitamin D Status and Clinical Presentation Among French Inpatients With Substance Use Disorders.Addiction biology · 2026Article
- Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review.Addiction neuroscience · 2025Article
- Early disruptions in vitamin D receptor signaling induces persistent developmental behavior deficits in zebrafish larvae.PloS one · 2025Article
- Vitamin D3 improves iminodipropionitrile-induced tic-like behavior in rats through regulation of GDNF/c-Ret signaling activity.European child & adolescent psychiatry · 2024Article
- The Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews.Current behavioral neuroscience reports · 2024Article
- Vitamin D Status and Behavioral Impulsivity in Anorexia Nervosa: Insights from a Longitudinal Study.Nutrients · 2024Article
- Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway.Experimental & molecular medicine · 2024Article
- Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction.Frontiers in psychiatry · 2024Review
- Effect of Vitamin D3 on Depressive Behaviors of Rats Exposed to Chronic Unpredictable Mild Stress.Biomedicines · 2023Article
- Microglia and Brain Disorders: The Role of Vitamin D and Its Receptor.International journal of molecular sciences · 2023Review
- The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders.Neuropsychiatric disease and treatment · 2023Review
- Functional Nutrition as Integrated Intervention for In- and Outpatient with Schizophrenia.Current neuropharmacology · 2023Article
- The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review.Current addiction reports · 2022Article
- Digital Addiction and Sleep.International journal of environmental research and public health · 2022Review
- Higher IgG level correlated with vitamin D receptor in the hippocampus of a pristane-induced lupus model.Clinical rheumatology · 2022Article
- Abnormal pattern of vitamin D receptor-associated genes and lncRNAs in patients with bipolar disorder.BMC psychiatry · 2022Article
- Understanding the role ofFrontiers in pharmacology · 2022Review
- The Vitamin D Role in Preventing Primary Headache in Adult and Pediatric Population.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The influence of micronutrients on dopamine systems is not well defined. Using mice, we show a potential role for reduced dietary vitamin D3 (cholecalciferol) in promoting diet-induced obesity (DIO), food intake, and drug consumption while on a high fat diet. To complement these deficiency studies, treatments with exogenous fully active vitamin D3 (calcitriol, 10 µg/kg, i.p.) were performed. Nondeficient mice that were made leptin resistant with a high fat diet displayed reduced food intake and body weight after an acute treatment with exogenous calcitriol. Dopamine neurons in the midbrain and their target neurons in the striatum were found to express vitamin D3 receptor protein. Acute calcitriol treatment led to transcriptional changes of dopamine-related genes in these regions in naive mice, enhanced amphetamine-induced dopamine release in both naive mice and rats, and increased locomotor activity after acute amphetamine treatment (2.5 mg/kg, i.p.). Alternatively, mice that were chronically fed either the reduced D3 high fat or chow diets displayed less activity after acute amphetamine treatment compared with their respective controls. Finally, high fat deficient mice that were trained to orally consume liquid amphetamine (90 mg/L) displayed increased consumption, while nondeficient mice treated with calcitriol showed reduced consumption. Our findings suggest that reduced dietary D3 may be a contributing environmental factor enhancing DIO as well as drug intake while eating a high fat diet. Moreover, these data demonstrate that dopamine circuits are modulated by D3 signaling, and may serve as direct or indirect targets for exogenous calcitriol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.