ArticleMolecular metabolism2016
Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia.
Article in Molecular metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 57 citations in OpenAlex.
- Article
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- Postbiotic Impact on Host Metabolism and Immunity Provides Therapeutic Potential in Metabolic Disease.Endocrine reviews · 2025Review
- Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice.Molecular metabolism · 2024Article
- Fecal microbiota transplantation ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota in db/db mice.BMJ open diabetes research & care · 2023Article
- Human liver microbiota modeling strategy at the early onset of fibrosis.BMC microbiology · 2023Article
- High fat diet-induced hyperlipidemia and tissue steatosis in rabbits through modulating ileal microbiota.Applied microbiology and biotechnology · 2022Article
- Postbiotics engage IRF4 in adipocytes to promote sex-dependent changes in blood glucose during obesity.Physiological reports · 2022Article
- Metagenomics Approach to the Intestinal Microbiome Structure and Abundance in High-Fat-Diet-Induced Hyperlipidemic Rat Fed with (-)-Epigallocatechin-3-Gallate Nanoparticles.Molecules (Basel, Switzerland) · 2022Article
- The role of T cells in age-related diseases.Nature reviews. Immunology · 2022Review
- Emerging concepts in intestinal immune control of obesity-related metabolic disease.Nature communications · 2021Review
- Immunological Impact of Intestinal T Cells on Metabolic Diseases.Frontiers in immunology · 2021Review
- Microbiota and Diabetes Mellitus: Role of Lipid Mediators.Nutrients · 2020Review
- Considerations for Gut Microbiota and Probiotics in Patients with Diabetes Amidst the Covid-19 Pandemic: A Narrative Review.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2020Review
- Management of Perianal Fistulas in Crohn's Disease.Visceral medicine · 2019Review
- Gut microbiome and microbial metabolites: a new system affecting metabolic disorders.Journal of endocrinological investigation · 2019Review
- Microbial and metabolomic remodeling by a formula of Sichuan dark tea improves hyperlipidemia in apoE-deficient mice.PloS one · 2019Article
- Intestinal Microbiota Contributes to Energy Balance, Metabolic Inflammation, and Insulin Resistance in Obesity.Journal of obesity & metabolic syndrome · 2017Review
- Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes.The Journal of nutrition · 2017Review
- Saccharomyces boulardii Administration Changes Gut Microbiota and Attenuates D-Galactosamine-Induced Liver Injury.Scientific reports · 2017Article
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk.
methodsWe triggered the immune system with microbial extracts specifically from the intestinal ileum contents of HFD-diabetic mice by the process of immunization. 35 days later, immunized mice were fed a HFD for up to two months in order to challenge the development of metabolic features. The immune responses were quantified. Eventually, adoptive transfer of immune cells from the microbiota-immunized mice to naïve mice was performed to demonstrate the causality of the microbiota-stimulated adaptive immune system on the development of metabolic disease. The gut microbiota of the immunized HFD-fed mice was characterized in order to demonstrate whether the manipulation of the microbiota to immune system interaction reverses the causal deleterious effect of gut microbiota dysbiosis on metabolic disease.
resultsSubcutaneous injection (immunization procedure) of ileum microbial extracts prevented hyperglycemia and insulin resistance in a dose-dependent manner in response to a HFD. The immunization enhanced the proliferation of CD4 and CD8 T cells in lymphoid organs, also increased cytokine production and antibody secretion. As a mechanism explaining the metabolic improvement, the immunization procedure reversed gut microbiota dysbiosis. Finally, adoptive transfer of immune cells from immunized mice improved metabolic features in response to HFD.
conclusionsGlycemia and insulin sensitivity can be regulated by triggering the adaptive immunity to microbiota interaction. This reduces the gut microbiota dysbiosis induced by a fat-enriched diet.
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