Evidence map›Paper›PMID 27257477›Full record

ReviewBoneKEy reports2016

The case for genome-wide association studies of bone acquisition in paediatric and adolescent populations.

John P Kemp, Carolina Medina-Gomez, Jonathan H Tobias, Fernando Rivadeneira, David M Evans

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BoneKEy reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Multidimensional Bone Density Phenotyping Reveals New Insights Into Genetic Regulation of the Pediatric Skeleton.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018
    Trial
  2. Article
  3. A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
    Article
  4. Using GWAS to identify novel therapeutic targets for osteoporosis.Translational research : the journal of laboratory and clinical medicine · 2017
    Review
  5. Genome-Wide Association Analysis of Longitudinal Bone Mineral Content Data From the Iowa Bone Development Study.Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

John P KempUniversity of Queensland Diamantina Institute, Level 5 Translational Research Institute, Brisbane, Queensland, Australia; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Joint first authors.
Carolina Medina-GomezDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Joint first authors.
Jonathan H TobiasSchool of Clinical Sciences, University of Bristol, Bristol, UK; Joint senior authors.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Joint senior authors.
David M EvansUniversity of Queensland Diamantina Institute, Level 5 Translational Research Institute, Brisbane, Queensland, Australia; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Joint senior authors.
Translational Research Institute · AUUniversity of Bristol · GBUniversity of Queensland · AU

Funding

Medical Research Council MC_UU_12013/4
6 · The paper itself

Abstract

Peak bone mass, the maximum amount of bone accrued at the end of the growth period, is an important predictor of future risk of osteoporosis and fracture. Hence, the contribution of genetic factors influencing bone accrual is of considerable interest to the osteoporosis research community. In this article, we review evidence that genetic factors play an important role in bone growth, describe the genetic loci implicated so far and briefly discuss lessons learned from the application of genome-wide association studies. Moreover, we attempt to make the case for genetic investigations of bone mineral density in paediatric and young adult populations, describing their potential to increase our knowledge of the process of bone metabolism throughout the life course, and in turn, identify novel targets for the pharmacological treatment of osteoporosis.

Identifiers

PMID27257477
PMCPMC4879864
OpenAlexW2407486926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.