ArticleJournal of contemporary brachytherapy2016
Image guided radiation therapy boost in combination with high-dose-rate intracavitary brachytherapy for the treatment of cervical cancer.
Article in Journal of contemporary brachytherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Deep learning-based multi-modality image conversion for evaluating dose calculation and position correction accuracy in image-guided radiation therapy.Radiological physics and technology · 2026Article
- Impact of the locking function of hybrid inverse planning optimization on the treatment plan quality of intracavitary/interstitial brachytherapy for locally advanced cervical cancer.Radiological physics and technology · 2026Article
- A Novel Positive-Contrast Magnetic Resonance Imaging Line Marker for High-Dose-Rate (HDR) MRI-Assisted Radiosurgery (MARS).Cancers · 2024Article
- Intensity-Modulated Radiation Therapy for Uterine Cervical Cancer to Reduce Toxicity and Enhance Efficacy - an Option or a Must?: A Narrative Review.Cancer research and treatment · 2024Review
- Generating synthetic CT from low-dose cone-beam CT by using generative adversarial networks for adaptive radiotherapy.Radiation oncology (London, England) · 2021Article
- An Inverse Dose Optimization Algorithm for Three-Dimensional Brachytherapy.Frontiers in oncology · 2020Article
- Dosimetric comparison of graphical optimization and inverse planning simulated annealing for brachytherapy of cervical cancer.Journal of contemporary brachytherapy · 2019Article
- Impact of different dose prescription schedules on EQDJournal of contemporary brachytherapy · 2019Article
- Clinical and dosimetric consequences of imperfect applicator insertion in cervical cancer brachytherapy.Journal of contemporary brachytherapy · 2018Article
- Image quality improvement in cone-beam CT using the super-resolution technique.Journal of radiation research · 2018Article
- Impact of brachytherapy technique (2D versus 3D) on outcome following radiotherapy of cervical cancer.Journal of contemporary brachytherapy · 2018Article
- Artificial neural network based gynaecological image-guided adaptive brachytherapy treatment planning correction of intra-fractional organs at risk dose variation.Journal of contemporary brachytherapy · 2017Article
- The usefulness of fleet rectal enemas on high-dose-rate intracavitary cervical cancer brachytherapy. A prospective trial.Journal of contemporary brachytherapy · 2017Article
- Computed tomography-based treatment planning for high-dose-rate brachytherapy using the tandem and ring applicator: influence of applicator choice on organ dose and inter-fraction adaptive planning.Journal of contemporary brachytherapy · 2017Review
- Influence of Field of View and Bowtie Filtration on Cone Beam Computed Tomography Image Quality and Scatter-to-Primary Ratio.Journal of medical physicsArticle
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to demonstrate the dosimetric and clinical feasibility of image guided radiation therapy (IGRT) combined with high-dose-rate (HDR) intracavitary brachytherapy (ICBT) to improve dose distribution in cervical cancer treatment. MATERIAL AND
methodsFor 42 cervical cancer patients, magnetic resonance imaging (MRI) scans were acquired after completion of whole pelvic irradiation 45-46 Gy and 5 fractions of B + I (ICBT + IGRT) treatment were subsequently received. The high risk clinical target volume (HRCTV), intermediate risk clinical target volume (IRCTV), bladder, rectum, and sigmoid were contoured on the computed tomography (CT) scans. The total planning aim doses for HRCTV was D90% > 85 Gy, whilst constraints for rectum and sigmoid were D2cc < 75 Gy and D2cc < 90 Gy for bladder in terms of an equivalent dose in 2 Gy (EQD2) for external beam radiotherapy (EBRT) and brachytherapy boost. The IGRT plan was optimized on top of the ICBT dose distribution. A dosimetric comparison was made between B + I and optimized ICBT (O-ICBT) only.
resultsThe mean D90% of HRCTV was comparable for B + I and O-ICBT (p = 0.82). For B + I plan, HRCTV D100%, IRCTV D100%, and IRCTV D90% were significantly increased by a mean of 10.52 Gy, 5.61 Gy, and 2.70 Gy, respectively (p < 0.01). The D2cc for bladder, rectum, and sigmoid were lower by a mean of 21.36, 6.78, and 10.65 Gy, respectively (p < 0.01). The mean rectum V60 Gy value over 42 patients was almost the same for both techniques but for bladder and sigmoid B + I had higher V60 Gy mean values as compared with the O-ICBT.
conclusionsB + I can improve dose distribution in cervical cancer treatment; it could be useful for tumors extended beyond the reach of intracavitary/interstitial brachytherapy (IC/ISBT) or for centers that are inexperienced or ill-equipped with IC/ISBT techniques. Additional confirmatory prospective studies with larger numbers of patients and longer follow-up are required to validate the durability.
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