ArticleJournal of clinical biochemistry and nutrition2016
Reactive oxygen species induced by non-steroidal anti-inflammatory drugs enhance the effects of photodynamic therapy in gastric cancer cells.
Article in Journal of clinical biochemistry and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Heme-porphyrin metabolism in photodynamic therapy associated with reactive oxygen species.Journal of clinical biochemistry and nutrition · 2026Article
- Parthenolide alleviates indomethacin-induced gastric ulcer in rats via antioxidant, anti-inflammatory, and antiapoptotic activities.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Reactive oxygen species induced by indomethacin enhance accumulation of heme carrier protein 1 and hematoporphyrin accumulationJournal of clinical biochemistry and nutrition · 2024Article
- Protective Effect of the Phycobiliproteins fromPlants (Basel, Switzerland) · 2023Article
- Acetic acid enhances the effect of photodynamic therapy in gastric cancer cells via the production of reactive oxygen species.Journal of clinical biochemistry and nutrition · 2022Article
- The Cytotoxicity of Doxorubicin Can Be Accelerated by a Combination of Hyperthermia and 5-Aminolevulinic Acid.Antioxidants (Basel, Switzerland) · 2021Article
- Porphylipoprotein Accumulation and Porphylipoprotein Photodynamic Therapy Effects Involving Cancer Cell-Specific Cytotoxicity.International journal of molecular sciences · 2021Article
- Genistein inhibits lung cancer cell stem-like characteristics by modulating MnSOD and FoxM1 expression.Oncology letters · 2020Article
- Direct detection of diclofenac radical produced by ultraviolet irradiation using electron spin resonance method.Journal of clinical biochemistry and nutrition · 2020Article
- Diclofenac Potentiates Sorafenib-Based Treatments of Hepatocellular Carcinoma by Enhancing Oxidative Stress.Cancers · 2019Article
- Article
- Hyperthermia enhances photodynamic therapy by regulation of HCP1 and ABCG2 expressions via high level ROS generation.Scientific reports · 2019Article
- Mitochondrial Reactive Oxygen Species and Photodynamic Therapy.Laser therapy · 2016Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy is useful for the treatment of cancer because it is minimally invasive for patients. Certain porphyrin compounds and their derivatives have been used as the photosensitizer because they accumulate specifically in cancerous tissues. However, the detailed mechanism of this phenomenon has not been clarified. We previously reported that a proton-coupled folate transporter, HCP1, transported porphyrins and that regulation of the protein was associated with cancer-specific reactive oxygen species from mitochondria (mitROS). Therefore, over-generation of mitROS could increase HCP1 expression and the effect of photodynamic therapy. We investigated whether pretreatment with indomethacin influenced photodynamic therapy by using a rat normal gastric mucosal cell line, RGM1, its cancer-like mutated cell line, RGK1, and a manganese superoxide dismutase (MnSOD)-overexpressing RGK cell line, RGK-MnSOD. Indomethacin promotes the generation of cellular mitROS by inhibiting the electron transport chain, and MnSOD scavenges the mitROS. We elucidated that indomethacin enhanced cancer-specific mitROS generation and increased HCP1 expression. Furthermore, RGK1 cells showed higher cellular incorporation of hematoporphyrin and better therapeutic effect with indomethacin treatment whereas RGK-MnSOD cells did not show a difference. Thus, we concluded that indomethacin improved the effect of photodynamic therapy by inducing increased mitROS generation in cancer cells.
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