ArticleNature communications2016
A two-neuron system for adaptive goal-directed decision-making in Lymnaea.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 31 citations in OpenAlex.
- Functional mapping of the molluscan brain guided by synchrotron X-ray tomography.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Division of labor for defensive retaliation and preemption by the peripheral and central nervous systems in the nudibranch Berghia.Current biology : CB · 2024Article
- A circuit mechanism linking past and future learning through shifts in perception.Science advances · 2023Article
- Secondary rewards acquire enhanced incentive motivation via increasing anticipatory activity of the lateral orbitofrontal cortex.Brain structure & function · 2021Article
- To eat or not to eat: a Garcia effect in pond snails (Lymnaea stagnalis).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Article
- Report on the First Symposium on Invertebrate Neuroscience held on 13-17th August 2019 at the Balaton Limnological Institute, MTA Centre for Ecological Research, Tihany, Hungary.Invertebrate neuroscience : IN · 2020Article
- Proactive and retroactive interference with associative memory consolidation in the snailCommunications biology · 2019Article
- A central control circuit for encoding perceived food value.Science advances · 2018Article
- Use of theJournal of neurophysiology · 2017Review
- A novel in vitro analog expressing learning-induced cellular correlates in distinct neural circuits.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- The foundations of plant intelligence.Interface focus · 2017Review
- Satiation level affects anti-predatory decisions in foraging juvenile crayfish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Impairment of the serotonergic neurons underlying reinforcement elicits extinction of the repeatedly reactivated context memory.Scientific reports · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
During goal-directed decision-making, animals must integrate information from the external environment and their internal state to maximize resource localization while minimizing energy expenditure. How this complex problem is solved by the nervous system remains poorly understood. Here, using a combined behavioural and neurophysiological approach, we demonstrate that the mollusc Lymnaea performs a sophisticated form of decision-making during food-searching behaviour, using a core system consisting of just two neuron types. The first reports the presence of food and the second encodes motivational state acting as a gain controller for adaptive behaviour in the absence of food. Using an in vitro analogue of the decision-making process, we show that the system employs an energy management strategy, switching between a low- and high-use mode depending on the outcome of the decision. Our study reveals a parsimonious mechanism that drives a complex decision-making process via regulation of levels of tonic inhibition and phasic excitation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.