Evidence map›Paper›PMID 27257071›Full record

ArticleNucleic acids research2016

Goldmine integrates information placing genomic ranges into meaningful biological contexts.

Jeffrey M Bhasin, Angela H Ting

Abstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jeffrey M BhasinDepartment of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Angela H TingDepartment of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA tinga@ccf.org.

Funding

Characterizing the DNA methylomes of indolent and aggressive prostate cancersR01CA154356 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI TING, ANGELA H · 2011 to 2015
$1.6M
The function of differential DNA methylation in aggressive prostate cancerF31CA195887 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI BHASIN, JEFFREY M · 2015 to 2016
$56k
Howard Hughes Medical InstituteNCI NIH HHS F31 CA195887NCI NIH HHS R01 CA154356
6 · The paper itself

Abstract

Bioinformatic analysis often produces large sets of genomic ranges that can be difficult to interpret in the absence of genomic context. Goldmine annotates genomic ranges from any source with gene model and feature contexts to facilitate global descriptions and candidate loci discovery. We demonstrate the value of genomic context by using Goldmine to elucidate context dynamics in transcription factor binding and to reveal differentially methylated regions (DMRs) with context-specific functional correlations. The open source R package and documentation for Goldmine are available at http://jeffbhasin.github.io/goldmine.

Indexed as

SoftwareComputational BiologyDNA MethylationGenomicsHigh-Throughput Nucleotide SequencingMolecular Sequence AnnotationProtein Binding

Identifiers

PMID27257071
PMCPMC4937336

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.