ArticleBiomolecules & therapeutics2016
Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.
Article in Biomolecules & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
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- Identification of phytochemicals in Qingfei Paidu decoction for the treatment of coronavirus disease 2019 by targeting the virus-host interactome.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- Oroxylin A shows limited antiviral activity towards dengue virus.BMC research notes · 2022Article
- Molecular docking study of variousFrontiers in microbiology · 2022Article
- Norwogonin attenuates hypoxia-induced oxidative stress and apoptosis in PC12 cells.BMC complementary medicine and therapies · 2021Article
- Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining.Frontiers in pharmacology · 2021Article
- Flavonoids as Antiviral Agents forViruses · 2020Review
- Principles and treatment strategies for the use of Chinese herbal medicine in patients at different stages of coronavirus infection.American journal of cancer research · 2020Review
- Polyphenols of Chinese skullcap roots: from chemical profiles to anticancer effects.RSC advances · 2019Review
- Role of Some Food-Grade Synthesized Flavonoids on the Control of Ochratoxin A inMolecules (Basel, Switzerland) · 2019Article
- Manassantin B shows antiviral activity against coxsackievirus B3 infection by activation of the STING/TBK-1/IRF3 signalling pathway.Scientific reports · 2019Article
- Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities.Journal of natural medicines · 2018Article
- Antiviral Activity of Itraconazole against Echovirus 30 InfectionOsong public health and research perspectives · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe complications associated with EV71 infections are a common cause of neonatal death. Lack of effective therapeutic agents for these infections underlines the importance of research for the development of new antiviral compounds. In the present study, the anti-EV71 activity of norwogonin, oroxylin A, and mosloflavone from Scutellaria baicalensis Georgi was evaluated using a cytopathic effect (CPE) reduction method, which demonstrated that all three compounds possessed strong anti-EV71 activity and decreased the formation of visible CPEs. Norwogonin, oroxylin A, and mosloflavone also inhibited virus replication during the initial stage of virus infection, and they inhibited viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. However, ribavirin has a relatively weaker efficacy compared to the other drugs. Therefore, these findings provide important information that will aid in the utilization of norwogonin, oroxylin A, and mosloflavone for EV71 treatment.
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