Evidence map›Paper›PMID 27257003›Full record

Trial reportThorax2016

Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial.

Bernie M Bissett, I Anne Leditschke, Teresa Neeman, Robert Boots, Jennifer Paratz

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 64 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 8 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04534296 narecruitingnot on this mapstarted 2021, after this paper: background citation

A Randomized Control Trial Comparing the Effects of Early Mobilization and Routine Care on Diaphragmatic Thickness

TypeinterventionalSponsorChildren's Hospital of Fudan UniversityRan2021 to 2025Enrolled160ConditionsMechanical Ventilation Complication, Ventilator-induced Diaphragm DysfunctionArmsearly mobilization, routine care
NCT05461898 narecruitingnot on this mapstarted 2023, after this paper: background citation

RehabGBs: Rehabilitation in People With Guillain-Barré Syndrome

TypeinterventionalSponsorCentro de Reabilitacao do NorteRan2023 to 2026Enrolled74ConditionsGuillain-Barré SyndromeArmsInpatient Rehabilitation, Inspiratory muscle training
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 8 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  9. Comparison of the timed inspiratory effort index with the T-piece trial as a decision-making tool for extubation: a randomized controlled non-inferiority trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
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  11. Improving respiratory muscle strength and health status in burn patients: a randomized controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
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  20. Blowing in the Wind: The Uncertain Impact of Inspiratory Muscle Strength Training in ICU Patients.American journal of respiratory and critical care medicine · 2025
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Bernie M BissettSchool of Medicine, University of Queensland, Brisbane, Queensland, Australia Discipline of Physiotherapy, University of Canberra, Australia Physiotherapy Department, Canberra Hospital, Canberra, Australian Capital Territory, Australia.
I Anne LeditschkeIntensive Care Unit, Canberra Hospital, Canberra, Australian Capital Territory, Australia Intensive Care Unit, Mater Hospital, Brisbane, Queensland, Australia School of Medicine, Australian National University, Canberra, Australian Capital Territory, Australia.
Teresa NeemanStatistical Consulting Unit, Australian National University, Canberra, Australian Capital Territory, Australia.
Robert BootsSchool of Medicine, University of Queensland, Brisbane, Queensland, Australia Intensive Care Unit, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Jennifer ParatzSchool of Medicine, University of Queensland, Brisbane, Queensland, Australia Intensive Care Unit, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia School of Alllied Health Sciences, Griffith University, Australia.
Australian National University · AUCanberra Hospital · AUGriffith University · AUUniversity of Canberra · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients who have been mechanically ventilated, inspiratory muscles remain weak and fatigable following ventilatory weaning, which may contribute to dyspnoea and limited functional recovery. Inspiratory muscle training may improve inspiratory muscle strength and endurance following weaning, potentially improving dyspnoea and quality of life in this patient group.

methodsWe conducted a randomised trial with assessor-blinding and intention-to-treat analysis. Following 48 hours of successful weaning, 70 participants (mechanically ventilated ≥7 days) were randomised to receive inspiratory muscle training once daily 5 days/week for 2 weeks in addition to usual care, or usual care (control). Primary endpoints were inspiratory muscle strength and fatigue resistance index (FRI) 2 weeks following enrolment. Secondary endpoints included dyspnoea, physical function and quality of life, post-intensive care length of stay and in-hospital mortality.

results34 participants were randomly allocated to the training group and 36 to control. The training group demonstrated greater improvements in inspiratory strength (training: 17%, control: 6%, mean difference: 11%, p=0.02). There were no statistically significant differences in FRI (0.03 vs 0.02, p=0.81), physical function (0.25 vs 0.25, p=0.97) or dyspnoea (-0.5 vs 0.2, p=0.22). Improvement in quality of life was greater in the training group (14% vs 2%, mean difference 12%, p=0.03). In-hospital mortality was higher in the training group (4 vs 0, 12% vs 0%, p=0.051).

conclusionsInspiratory muscle training following successful weaning increases inspiratory muscle strength and quality of life, but we cannot confidently rule out an associated increased risk of in-hospital mortality. TRIAL REGISTRATION NUMBER: ACTRN12610001089022, results.

Indexed as

AdultAgedBreathing ExercisesDyspneaFemaleHumansInhalationLength of StayMaleMiddle AgedPatient ComplianceQuality of LifeRespiration, ArtificialRespiratory MusclesRespiratory TherapySingle-Blind MethodExerciseRespiratory MeasurementRespiratory Muscles

Identifiers

PMID27257003
PMCPMC5013088
OpenAlexW2419523696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.