ArticleDevelopment (Cambridge, England)2016
Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- The conserved microtubule-associated protein Mini Spindles promotes dendrite branching and limits terminal branch elongation inmicroPublication biology · 2026Article
- Article
- Regulation of theRNA (New York, N.Y.) · 2024Article
- Transcriptional pausing factor M1BP regulates cellular homeostasis by suppressing autophagy and apoptosis inAutophagy reports · 2023Article
- Article
- Drosophila FMRP controls miR-276-mediated regulation of nejire mRNA for space-filling dendrite development.G3 (Bethesda, Md.) · 2022Article
- Non-Canonical Roles of Apoptotic Caspases in the Nervous System.Frontiers in cell and developmental biology · 2022Review
- The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth.PLoS genetics · 2020Article
- Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs.Nucleic acids research · 2020Article
- Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Physiological functions of non-apoptotic caspase activity in the nervous system.Seminars in cell & developmental biology · 2018Review
- Review
- Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.Nucleic acids research · 2018Article
- Recent advances in branching mechanisms underlying neuronal morphogenesis.F1000Research · 2018Review
- No significant regulation of bicoid mRNA by Pumilio or Nanos in the early Drosophila embryo.PloS one · 2018Article
- Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins.RNA biology · 2017Article
- Enclosure of Dendrites by Epidermal Cells Restricts Branching and Permits Coordinated Development of Spatially Overlapping Sensory Neurons.Cell reports · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Dendritic arbor morphology is a key determinant of neuronal function. Once established, dendrite branching patterns must be maintained as the animal develops to ensure receptive field coverage. The translational repressors Nanos (Nos) and Pumilio (Pum) are required to maintain dendrite growth and branching of Drosophila larval class IV dendritic arborization (da) neurons, but their specific regulatory role remains unknown. We show that Nos-Pum-mediated repression of the pro-apoptotic gene head involution defective (hid) is required to maintain a balance of dendritic growth and retraction in class IV da neurons and that upregulation of hid results in decreased branching because of an increase in caspase activity. The temporal requirement for nos correlates with an ecdysone-triggered switch in sensitivity to apoptotic stimuli that occurs during the mid-L3 transition. We find that hid is required during pupariation for caspase-dependent pruning of class IV da neurons and that Nos and Pum delay pruning. Together, these results suggest that Nos and Pum provide a crucial neuroprotective regulatory layer to ensure that neurons behave appropriately in response to developmental cues.
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Registered trials
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