Evidence map›Paper›PMID 27256856›Full record

ArticleAJNR. American journal of neuroradiology2016

Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation.

Y Zhang, S A Gauthier, A Gupta, W Chen, J Comunale, G C-Y Chiang, D Zhou, G Askin, W Zhu, D Pitt and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  11. Review
  12. In vivo imaging of chronic active lesions in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
    Review
  13. Article
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  15. CombiningFrontiers in neuroscience · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Y ZhangFrom the Department of Radiology (Y.Z., W.C., W.Z.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Departments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.).ORCID 0000-0002-2251-3777
S A GauthierNeurology (S.A.G.).ORCID 0000-0002-4015-1781
A GuptaDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.).ORCID 0000-0003-2816-0340
W ChenFrom the Department of Radiology (Y.Z., W.C., W.Z.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0001-8014-2364
J ComunaleDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.).ORCID 0000-0001-6063-0109
G C-Y ChiangDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.).ORCID 0000-0001-9925-0816
D ZhouDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.).ORCID 0000-0002-5436-6177
G AskinHealthcare Policy and Research (G.A.), Weill Cornell Medical College, New York, New York.ORCID 0000-0001-5126-9809
W ZhuFrom the Department of Radiology (Y.Z., W.C., W.Z.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-0254-6563
D PittDepartment of Neurology (D.P.), School of Medicine, Yale University, New Haven, Connecticut.ORCID 0000-0002-6407-9542
Y WangDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.) Department of Biomedical Engineering (Y.W.), Cornell University, Ithaca, New York. yiwang@med.cornell.edu.ORCID 0000-0003-1404-8526
ZTE (United States) · USTongji Hospital · CNCornell University · USNeurology, Inc · USYale University · US

Funding

Multiple Sclerosis Lesion Magnetic Susceptibility ActivityR01NS090464 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2015 to 2020
$2.3M
Analyses of gradient echo MRI dataR01EB013443 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2011 to 2014
$1.5M
NIBIB NIH HHS R01 EB013443NINDS NIH HHS R01 NS090464
6 · The paper itself

Abstract

background and purposeQuantitative susceptibility mapping and R2* are sensitive to myelin and iron changes in multiple sclerosis lesions. This study was designed to characterize lesion changes on quantitative susceptibility mapping and R2* at various gadolinium-enhancement stages. MATERIALS AND

methodsThis study included 64 patients with MS with different enhancing patterns in white matter lesions: nodular, shell-like, nonenhancing < 1 year old, and nonenhancing 1-3 years old. These represent acute, late acute, early chronic, and late chronic lesions, respectively. Susceptibility values measured on quantitative susceptibility mapping and R2* values were compared among the 4 lesion types. Their differences were assessed with a generalized estimating equation, controlling for Expanded Disability Status Scale score, age, and disease duration.

resultsWe analyzed 203 lesions: 80 were nodular-enhancing, of which 77 (96.2%) were isointense on quantitative susceptibility mapping; 33 were shell-enhancing, of which 30 (90.9%) were hyperintense on quantitative susceptibility mapping; and 49 were nonenhancing lesions < 1 year old and 41 were nonenhancing lesions 1-3 years old, all of which were hyperintense on quantitative susceptibility mapping. Their relative susceptibility/R2* values were 0.5 ± 4.4 parts per billion/-5.6 ± 2.9 Hz, 10.2 ± 5.4 parts per billion/-8.0 ± 2.6 Hz, 20.2 ± 7.8 parts per billion/-3.1 ± 2.3 Hz, and 33.2 ± 8.2 parts per billion/-2.0 ± 2.6 Hz, respectively, and were significantly different (P < .005).

conclusionsEarly active MS lesions with nodular enhancement show R2* decrease but no quantitative susceptibility mapping change, reflecting myelin breakdown; late active lesions with peripheral enhancement show R2* decrease and quantitative susceptibility mapping increase in the lesion center, reflecting further degradation and removal of myelin debris; and early or late chronic nonenhancing lesions show both quantitative susceptibility mapping and R2* increase, reflecting iron accumulation.

Indexed as

AdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisMyelin SheathWhite Matter

Identifiers

PMID27256856
PMCPMC5018433
OpenAlexW2414633822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.