ArticleScientific reports2016
Electrical Oscillations in Two-Dimensional Microtubular Structures.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Oscillatory dynamics in paclitaxel-proteinoid networks.Discover molecules · 2026Article
- Electrical oscillations in microtubules.Scientific reports · 2025Article
- Electrical Oscillations in Microtubules.bioRxiv : the preprint server for biology · 2025Article
- Consciousness and spintronic coherence in microtubules.Communicative & integrative biology · 2025Article
- Brain Microtubule Electrical Oscillations-Empirical Mode Decomposition Analysis.Cellular and molecular neurobiology · 2023Article
- The electrical properties of isolated microtubules.Scientific reports · 2023Article
- Role of the microtubules in the electrical activity of the primary cilium of renal epithelial cells.Frontiers in molecular biosciences · 2023Article
- Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code.International journal of molecular sciences · 2022Review
- Consciousness, Cognition and the Neuronal Cytoskeleton - A New Paradigm Needed in Neuroscience.Frontiers in molecular neuroscience · 2022Article
- Electrical recordings from dendritic spines of adult mouse hippocampus and effect of the actin cytoskeleton.Frontiers in molecular neuroscience · 2022Article
- Low-energy amplitude-modulated radiofrequency electromagnetic fields as a systemic treatment for cancer: Review and proposed mechanisms of action.Frontiers in medical technology · 2022Review
- Calcium signal transmission by axonemal microtubules as an optimized information pathway in cilia and flagella.Journal of bioenergetics and biomembranes · 2021Article
- Electrical behaviour and evolutionary computation in thin films of bovine brain microtubules.Scientific reports · 2021Article
- Honeybee Brain Oscillations Are Generated by Microtubules. The Concept of a Brain Central Oscillator.Frontiers in molecular neuroscience · 2021Article
- Primary Cilia and Calcium Signaling Interactions.International journal of molecular sciences · 2020Review
- Bioelectrical and cytoskeletal patterns correlate with altered axial polarity in the follicular epithelium of the Drosophila mutant gurken.BMC developmental biology · 2020Article
- Investigation of the Electrical Properties of Microtubule Ensembles under Cell-Like Conditions.Nanomaterials (Basel, Switzerland) · 2020Article
- Two-Dimensional Brain Microtubule Structures Behave as Memristive Devices.Scientific reports · 2019Article
- Physical energies to the rescue of damaged tissues.World journal of stem cells · 2019Review
- Bundles of Brain Microtubules Generate Electrical Oscillations.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubules (MTs) are unique components of the cytoskeleton formed by hollow cylindrical structures of αβ tubulin dimeric units. The structural wall of the MT is interspersed by nanopores formed by the lateral arrangement of its subunits. MTs are also highly charged polar polyelectrolytes, capable of amplifying electrical signals. The actual nature of these electrodynamic capabilities remains largely unknown. Herein we applied the patch clamp technique to two-dimensional MT sheets, to characterize their electrical properties. Voltage-clamped MT sheets generated cation-selective oscillatory electrical currents whose magnitude depended on both the holding potential, and ionic strength and composition. The oscillations progressed through various modes including single and double periodic regimes and more complex behaviours, being prominent a fundamental frequency at 29 Hz. In physiological K(+) (140 mM), oscillations represented in average a 640% change in conductance that was also affected by the prevalent anion. Current injection induced voltage oscillations, thus showing excitability akin with action potentials. The electrical oscillations were entirely blocked by taxol, with pseudo Michaelis-Menten kinetics and a KD of ~1.29 μM. The findings suggest a functional role of the nanopores in the MT wall on the genesis of electrical oscillations that offer new insights into the nonlinear behaviour of the cytoskeleton.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.