Evidence map›Paper›PMID 27256671›Full record

ArticleStroke2016

Postmenopausal Hormone Therapy and Risk of Stroke: Impact of the Route of Estrogen Administration and Type of Progestogen.

Marianne Canonico, Laure Carcaillon, Geneviève Plu-Bureau, Emmanuel Oger, Archana Singh-Manoux, Pascale Tubert-Bitter, Alexis Elbaz, Pierre-Yves Scarabin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 150 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Hormonal Changes in Women with Epilepsy.Neuropsychiatric disease and treatment · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Marianne CanonicoFrom the Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, INSERM UMRS1018, Villejuif, France (M.C., E.O., A.S.-M., A.E., P.-Y.S.); Institut de veille sanitaire (InVS), Département des Maladies Chroniques et des, Traumatismes, F-94415 Saint-Maurice, France (L.C.); APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes (G.P.-B.); Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France (P.T.-B.); and Institut Pasteur, Paris, France (P.T.-B.). marianne.canonico@inserm.fr.
Laure CarcaillonFrom the Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, INSERM UMRS1018, Villejuif, France (M.C., E.O., A.S.-M., A.E., P.-Y.S.); Institut de veille sanitaire (InVS), Département des Maladies Chroniques et des, Traumatismes, F-94415 Saint-Maurice, France (L.C.); APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes (G.P.-B.); Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France (P.T.-B.); and Institut Pasteur, Paris, France (P.T.-B.).
Geneviève Plu-BureauFrom the Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, INSERM UMRS1018, Villejuif, France (M.C., E.O., A.S.-M., A.E., P.-Y.S.); Institut de veille sanitaire (InVS), Département des Maladies Chroniques et des, Traumatismes, F-94415 Saint-Maurice, France (L.C.); APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes (G.P.-B.); Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France (P.T.-B.); and Institut Pasteur, Paris, France (P.T.-B.).
Emmanuel OgerFrom the Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, INSERM UMRS1018, Villejuif, France (M.C., E.O., A.S.-M., A.E., P.-Y.S.); Institut de veille sanitaire (InVS), Département des Maladies Chroniques et des, Traumatismes, F-94415 Saint-Maurice, France (L.C.); APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes (G.P.-B.); Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France (P.T.-B.); and Institut Pasteur, Paris, France (P.T.-B.).
Archana Singh-ManouxFrom the Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, INSERM UMRS1018, Villejuif, France (M.C., E.O., A.S.-M., A.E., P.-Y.S.); Institut de veille sanitaire (InVS), Département des Maladies Chroniques et des, Traumatismes, F-94415 Saint-Maurice, France (L.C.); APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes (G.P.-B.); Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France (P.T.-B.); and Institut Pasteur, Paris, France (P.T.-B.).
Pascale Tubert-BitterFrom the Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, INSERM UMRS1018, Villejuif, France (M.C., E.O., A.S.-M., A.E., P.-Y.S.); Institut de veille sanitaire (InVS), Département des Maladies Chroniques et des, Traumatismes, F-94415 Saint-Maurice, France (L.C.); APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes (G.P.-B.); Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France (P.T.-B.); and Institut Pasteur, Paris, France (P.T.-B.).
Alexis ElbazFrom the Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, INSERM UMRS1018, Villejuif, France (M.C., E.O., A.S.-M., A.E., P.-Y.S.); Institut de veille sanitaire (InVS), Département des Maladies Chroniques et des, Traumatismes, F-94415 Saint-Maurice, France (L.C.); APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes (G.P.-B.); Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France (P.T.-B.); and Institut Pasteur, Paris, France (P.T.-B.).
Pierre-Yves ScarabinFrom the Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, INSERM UMRS1018, Villejuif, France (M.C., E.O., A.S.-M., A.E., P.-Y.S.); Institut de veille sanitaire (InVS), Département des Maladies Chroniques et des, Traumatismes, F-94415 Saint-Maurice, France (L.C.); APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes (G.P.-B.); Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France (P.T.-B.); and Institut Pasteur, Paris, France (P.T.-B.).
Université de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris Cité · FRUniversité Paris-Sud · FRCentre de recherche en Epidémiologie et Santé des Populations · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe benefit/risk analysis of hormone therapy in postmenopausal women is not straightforward and depends on cardiovascular disease. Evidence supports the safety of transdermal estrogens and the importance of progestogens for thrombotic risk. However, the differential association of oral and transdermal estrogens with stroke remains poorly investigated. Furthermore, there are no data regarding the impact of progestogens.

methodsWe set up a nested case-control study of ischemic stroke (IS) within all French women aged 51 to 62 years between 2009 and 2011 without personal history of cardiovascular disease or contraindication to hormone therapy. Participants were identified using the French National Health Insurance database, which includes complete drug claims for the past 3 years and French National hospital data. We identified 3144 hospitalized IS cases who were matched for age and zip code to 12 158 controls. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI).

resultsCompared with nonusers, the adjusted ORs of IS were1.58 (95% CI, 1.01-2.49) in oral estrogen users and 0.83 (0.56-1.24) in transdermal estrogens users (P<0.01). There was no association of IS with use of progesterone (OR, 0.78; 95% CI, 0.49-1.26), pregnanes (OR, 1.00; 95% CI, 0.60-1.67), and nortestosterones (OR, 1.26; 95% CI, 0.62-2.58), whereas norpregnanes increased IS risk (OR, 2.25; 95% CI, 1.05-4.81).

conclusionsBoth route of estrogen administration and progestogens were important determinants of IS. Our findings suggest that transdermal estrogens might be the safest option for short-term hormone therapy use.

Indexed as

PostmenopauseAdministration, CutaneousAdministration, OralBrain IschemiaCase-Control StudiesEstrogensFemaleFranceHormone Replacement TherapyHumansIncidenceMiddle AgedProgestinsRisk FactorsStrokeEstrogensProgestinsepidemiologyhormonesstrokewomen

Identifiers

PMID27256671
PMCPMC4927222
OpenAlexW2413993750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.