ArticleScientific reports2016
Non-random distribution of homo-repeats: links with biological functions and human diseases.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- eIF2D promotes 40S ribosomal subunit recycling during intrinsic ribosome destabilization.Nucleic acids research · 2025Article
- Low-complexity regions in fungi display functional groups and are depleted in positively charged amino acids.NAR genomics and bioinformatics · 2025Article
- Terminal regions of a protein are a hotspot for low complexity regions and selection.Open biology · 2024Article
- Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes.Nature communications · 2022Article
- The sequence context in poly-alanine regions: structure, function and conservation.Bioinformatics (Oxford, England) · 2022Article
- Expansion and functional analysis of the SR-related protein family across the domains of life.RNA (New York, N.Y.) · 2022Article
- DbStRiPs: Database of structural repeats in proteins.Protein science : a publication of the Protein Society · 2022Article
- Regions with two amino acids in protein sequences: A step forward from homorepeats into the low complexity landscape.Computational and structural biotechnology journal · 2022Article
- The evolutionary conserved TLDc domain defines a new class of (HScientific reports · 2021Article
- Between Interactions and Aggregates: The PolyQ Balance.Genome biology and evolution · 2021Article
- LCD-Composer: an intuitive, composition-centric method enabling the identification and detailed functional mapping of low-complexity domains.NAR genomics and bioinformatics · 2021Article
- Amino acid homorepeats in proteins.Nature reviews. Chemistry · 2020Review
- Disordered Residues and Patterns in the Protein Data Bank.Molecules (Basel, Switzerland) · 2020Article
- Article
- Atypical structural tendencies among low-complexity domains in the Protein Data Bank proteome.PLoS computational biology · 2020Article
- Proteome-scale relationships between local amino acid composition and protein fates and functions.PLoS computational biology · 2018Article
- Glutamine Codon Usage and polyQ Evolution in Primates Depend on the Q Stretch Length.Genome biology and evolution · 2018Article
- Proteome-scale understanding of relationship between homo-repeat enrichments and protein aggregation properties.PloS one · 2018Article
- Enrichment of Circular Code Motifs in the Genes of the Yeast Saccharomyces cerevisiae.Life (Basel, Switzerland) · 2017Article
- dAPE: a web server to detect homorepeats and follow their evolution.Bioinformatics (Oxford, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 hereditary diseases. Analysing 122 bacterial and eukaryotic genomes, we observed that the number of proteins containing homo-repeats is significantly larger than expected from theoretical estimates. Analysis of statistical significance indicates that the minimal size of homo-repeats varies with amino acid type and proteome. In an attempt to characterize proteins harbouring long homo-repeats, we found that those containing polar or small amino acids S, P, H, E, D, K, Q and N are enriched in structural disorder as well as protein- and RNA-interactions. We observed that E, S, Q, G, L, P, D, A and H homo-repeats are strongly linked with occurrence in human diseases. Moreover, S, E, P, A, Q, D and T homo-repeats are significantly enriched in neuronal proteins associated with autism and other disorders. We release a webserver for further exploration of homo-repeats occurrence in human pathology at http://bioinfo.protres.ru/hradis/.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.