Evidence map›Paper›PMID 27256508›Full record

ArticleNeuroscience2016

The intercalated nuclear complex of the primate amygdala.

Basilis Zikopoulos, Yohan J John, Miguel Ángel García-Cabezas, Jamie G Bunce, Helen Barbas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Rehydration of Freeze Substituted Brain Tissue for Pre-embedding Immunoelectron Microscopy.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2023
    Article
  10. Subgenual and Hippocampal Pathways in Amygdala Are Set to Balance Affect and Context Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  11. Review
  12. Amygdala Intercalated Cells: Gate Keepers and Conveyors of Internal State to the Circuits of Emotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
  13. Article
  14. The role of the amygdala in processing social and affective touch.Current opinion in behavioral sciences · 2022
    Article
  15. Prefrontal cortex interactions with the amygdala in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  16. The prefrontal cortex, pathological anxiety, and anxiety disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Review
  17. Article
  18. Evolution, Emotion, and Episodic Engagement.The American journal of psychiatry · 2021
    Review
  19. Article
  20. Serial Prefrontal Pathways Are Positioned to Balance Cognition and Emotion in Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Basilis ZikopoulosHuman Systems Neuroscience Laboratory, Department of Health Sciences, Boston University, Boston, MA, United States; Graduate Program for Neuroscience, Boston University and School of Medicine, Boston, MA, United States. Electronic address: zikopoul@bu.edu.
Yohan J JohnNeural Systems Laboratory, Department of Health Sciences, Boston University, Boston, MA, United States.
Miguel Ángel García-CabezasNeural Systems Laboratory, Department of Health Sciences, Boston University, Boston, MA, United States.
Jamie G BunceNeural Systems Laboratory, Department of Health Sciences, Boston University, Boston, MA, United States.
Helen BarbasGraduate Program for Neuroscience, Boston University and School of Medicine, Boston, MA, United States; Neural Systems Laboratory, Department of Health Sciences, Boston University, Boston, MA, United States.
Boston University · US

Funding

ORGANIZATION OF PREFRONTAL FEEDBACK CIRCUITSR01MH057414 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BARBAS, HELEN · 1999 to 2020
$7.3M
Prefrontal Anatomic Pathways in Executive ControlR01NS024760 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BARBAS, HELEN · 1987 to 2017
$6.7M
Organization of Excitatory and Inhibitory Circuits in ASDR01MH101209 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI ZIKOPOULOS, VASILEIOS · 2014 to 2018
$2.0M
NIMH NIH HHS R01 MH057414NIMH NIH HHS R01 MH101209NINDS NIH HHS R01 NS024760
6 · The paper itself

Abstract

The organization of the inhibitory intercalated cell masses (IM) of the primate amygdala is largely unknown despite their key role in emotional processes. We studied the structural, topographic, neurochemical and intrinsic connectional features of IM neurons in the rhesus monkey brain. We found that the intercalated neurons are not confined to discrete cell clusters, but form a neuronal net that is interposed between the basal nuclei and extends to the dorsally located anterior, central, and medial nuclei of the amygdala. Unlike the IM in rodents, which are prominent in the anterior half of the amygdala, the primate inhibitory net stretched throughout the antero-posterior axis of the amygdala, and was most prominent in the central and posterior extent of the amygdala. There were two morphologic types of intercalated neurons: spiny and aspiny. Spiny neurons were the most abundant; their somata were small or medium size, round or elongated, and their dendritic trees were round or bipolar, depending on location. The aspiny neurons were on average slightly larger and had varicose dendrites with no spines. There were three non-overlapping neurochemical populations of IM neurons, in descending order of abundance: (1) Spiny neurons that were positive for the striatal associated dopamine- and cAMP-regulated phosphoprotein (DARPP-32+); (2) Aspiny neurons that expressed the calcium-binding protein calbindin (CB+); and (3) Aspiny neurons that expressed nitric oxide synthase (NOS+). The unique combinations of structural and neurochemical features of the three classes of IM neurons suggest different physiological properties and function. The three types of IM neurons were intermingled and likely interconnected in distinct ways, and were innervated by intrinsic neurons within the amygdala, or by external sources, in pathways that underlie fear conditioning and anxiety.

Indexed as

AmygdalaAnimalsCalbindinsCell CountDendritesDopamine and cAMP-Regulated Phosphoprotein 32FemaleGABAergic NeuronsImaging, Three-DimensionalImmunohistochemistryInterneuronsMacaca mulattaMaleMicroscopy, ConfocalMicroscopy, ElectronMicroscopy, FluorescenceCalbindinsDopamine and cAMP-Regulated Phosphoprotein 32NADPNitric Oxide SynthaseReceptors, Dopamine D1anxietyconnectivityemotioninhibitionmedium spinyquantitative anatomy

Identifiers

PMID27256508
PMCPMC4928580
OpenAlexW2417963637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.