ArticleAdvances in experimental medicine and biology2016
Experimental and Computational Considerations in the Study of RNA-Binding Protein-RNA Interactions.
Article in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Signal or noise? RNA-binding proteins and the challenges of binding site assignments.Nucleic acids research · 2026Review
- Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcripts.PLoS pathogens · 2021Article
- Conserved long-range base pairings are associated with pre-mRNA processing of human genes.Nature communications · 2021Article
- Large-scale tethered function assays identify factors that regulate mRNA stability and translation.Nature structural & molecular biology · 2020Article
- CG14906 (mettl4) mediates mCell discovery · 2020Article
- Practical considerations on performing and analyzing CLIP-seq experiments to identify transcriptomic-wide RNA-protein interactions.Methods (San Diego, Calif.) · 2019Review
- Advances and challenges in the detection of transcriptome-wide protein-RNA interactions.Wiley interdisciplinary reviews. RNA · 2018Review
- NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.RNA (New York, N.Y.) · 2017Article
- Purification of Transcript-Specific mRNP Complexes Formed In Vivo from Saccharomyces cerevisiae.Methods in molecular biology (Clifton, N.J.) · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
After an RNA is transcribed, it undergoes a variety of processing steps that can change the encoded protein sequence (through alternative splicing and RNA editing), regulate the stability of the RNA, and control subcellular localization, timing, and rate of translation. The recent explosion in genomics techniques has enabled transcriptome-wide profiling of RNA processing in an unbiased manner. However, it has also brought with it both experimental challenges in developing improved methods to probe distinct processing steps, as well as computational challenges in data storage, processing, and analysis tools to enable large-scale interpretation in the genomics era. In this chapter we review experimental techniques and challenges in profiling various aspects of RNA processing, as well as recent efforts to develop analyses integrating multiple data sources and techniques to infer RNA regulatory networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.