Evidence map›Paper›PMID 27256330›Full record

ArticleLipids2016

Maternal Flaxseed Oil During Lactation Enhances Bone Development in Male Rat Pups.

Aline D'Avila Pereira, Danielle Cavalcante Ribeiro, Fernanda Carvalho de Santana, Aline de Sousa Dos Santos, Jorge Mancini-Filho, Celly Cristina Alves do Nascimento-Saba, Luis Guillermo Coca Velarde, Carlos Alberto Soares da Costa, Gilson Teles Boaventura

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Lipids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Aline D'Avila PereiraLaboratory of Experimental Nutrition, Department of Nutrition and Dietetics, Fluminense Federal University, Rua Mário Santos Braga 30, Niterói, RJ, 24020-140, Brazil. alinedape@gmail.com.
Danielle Cavalcante RibeiroLaboratory of Experimental Nutrition, Department of Nutrition and Dietetics, Fluminense Federal University, Rua Mário Santos Braga 30, Niterói, RJ, 24020-140, Brazil.
Fernanda Carvalho de SantanaLaboratory of Lipids, Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Aline de Sousa Dos SantosPhysiological Sciences, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Jorge Mancini-FilhoLaboratory of Lipids, Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Celly Cristina Alves do Nascimento-SabaPhysiological Sciences, Institute of Biology Roberto Alcantara Gomes, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Luis Guillermo Coca VelardeDepartment of Statistics, Fluminense Federal University, Niterói, RJ, Brazil.
Carlos Alberto Soares da CostaLaboratory of Experimental Nutrition, Department of Nutrition and Dietetics, Fluminense Federal University, Rua Mário Santos Braga 30, Niterói, RJ, 24020-140, Brazil.
Gilson Teles BoaventuraLaboratory of Experimental Nutrition, Department of Nutrition and Dietetics, Fluminense Federal University, Rua Mário Santos Braga 30, Niterói, RJ, 24020-140, Brazil.
Universidade Federal Fluminense · BRUniversidade de São Paulo · BRUniversidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flaxseed oil is an alpha linolenic acid source important in the growth and body development stage; furthermore, this acid acts on adipose tissue and bone health. The aim of this study was to evaluate body composition, fatty acid composition, hormone profile, retroperitoneal adipocyte area and femur structure of pups at weaning, whose mothers were fed a diet containing flaxseed oil during lactation. After birth, pups were randomly assigned: control (C, n = 12) and flaxseed oil (FO, n = 12), rats whose mothers were treated with diet containing soybean or flaxseed oil. At 21 days, the pups were weaned and body mass, length, body composition, biochemical parameter, leptin, osteoprotegerin, osteocalcin, fatty acids composition, intra-abdominal fat mass and femur structure were analyzed. FO showed (p < 0.05): higher body mass (+12 %) and length (+9 %); body fat mass (g, +45 %); bone mineral density (+8 %), bone mineral content (+55 %) and bone area (+35 %), osteocalcin (+173 %) and osteoprotegerin (+183 %). Arachidonic acid was lower (p < 0.0001), alpha-linolenic and eicosapentaenoic were higher (p < 0.0001). Intra-abdominal fat mass was higher (+25 %), however, the retroperitoneal adipocytes area was lower (-44 %). Femur mass (+10 %), distance between epiphyses (+4 %) and bone mineral density (+13 %) were higher. The study demonstrates that adequate flaxseed oil content during a lactation diet plays an important role in the development of pups.

Indexed as

AnimalsBody CompositionBody Mass IndexFatty AcidsFemaleFemurIntra-Abdominal FatLactationLinseed OilMaleOsteocalcinOsteoprotegerinPregnancyRandom AllocationRatsSoybean OilFatty AcidsLinseed OilOsteocalcinOsteoprotegerinSoybean OilTnfrsf11b protein, mouseAdiposityBoneFlaxseed oilLactationRats

Identifiers

PMID27256330
OpenAlexW2415220308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.