ArticleThe journal of physiological sciences : JPS2017
Nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors.
Article in The journal of physiological sciences : JPS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease.Translational neurodegeneration · 2025Article
- Opinion: exploring alternative pathways to neuroprotection-nicotine and carbon monoxide as antioxidative factors in neurodegeneration and delirium.Frontiers in neurology · 2025Article
- Nicotinic regulation of microglia: potential contributions to addiction.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Smoking, tobacco dependence, and neurometabolites in the dorsal anterior cingulate cortex.Molecular psychiatry · 2023Article
- Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity.Scientific reports · 2023Article
- Evidence for a protective effect of the loss of α4-containing nicotinic acetylcholine receptors on Aβ-related neuropathology in Tg2576 mice.Frontiers in neuroscience · 2023Article
- Nicotine-mediated effects in neuronal and mouse models of synucleinopathy.Frontiers in neuroscience · 2023Article
- Article
- Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.Journal of neuroinflammation · 2022Article
- The Role of α7nAChR-Mediated Cholinergic Anti-inflammatory Pathway in Immune Cells.Inflammation · 2021Review
- Changing Functional Signatures of Microglia along the Axis of Brain Aging.International journal of molecular sciences · 2021Review
- Glial cells as therapeutic targets for smoking cessation.Neuropharmacology · 2020Review
- Review
- Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models.Current topics in behavioral neurosciences · 2020Article
- Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal.Science advances · 2019Article
- Glial mechanisms underlying substance use disorders.The European journal of neuroscience · 2019Review
- Effect of overnight smoking abstinence on a marker for microglial activation: a [Psychopharmacology · 2018Article
- Time-course investigation of blood-brain barrier permeability and tight junction protein changes in a rat model of permanent focal ischemia.The journal of physiological sciences : JPS · 2018Article
- Interactions of Tryptophan and Its Catabolites With Melatonin and the Alpha 7 Nicotinic Receptor in Central Nervous System and Psychiatric Disorders: Role of the Aryl Hydrocarbon Receptor and Direct Mitochondria Regulation.International journal of tryptophan research : IJTR · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha 7 subunits of nicotinic acetylcholine receptors (nAChRs) are expressed in microglia and are involved in the suppression of neuroinflammation. Over the past decade, many reports show beneficial effects of nicotine, though little is known about the mechanism. Here we show that nicotine inhibits lipopolysaccharide (LPS)-induced proton (H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.