Evidence map›Paper›PMID 27255899›Full record

ArticleNanoscale research letters2016

Synergistic Effects of Gold Nanocages in Hyperthermia and Radiotherapy Treatment.

Ai-Wei Zhang, Wei-Hua Guo, Ya-Fei Qi, Jian-Zhen Wang, Xiang-Xing Ma, De-Xin Yu

Abstract read
In one paragraph

Article in Nanoscale research letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  7. Application of nano-radiosensitizers in combination cancer therapy.Bioengineering & translational medicine · 2023
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  12. Plasmonic Photothermal Nanoparticles for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ai-Wei ZhangDepartment of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China.
Wei-Hua GuoKey Laboratory of Colloid and Interface Chemistry, Ministry of Education, Department of Chemistry, Shandong University, Jinan, People's Republic of China.
Ya-Fei QiDepartment of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China.
Jian-Zhen WangDepartment of Radiotherapy, Qilu Hospital, Shandong University, Jinan, People's Republic of China.
Xiang-Xing MaDepartment of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China. xiangxingma2006@163.com.
De-Xin YuDepartment of Radiology, Qilu Hospital, Shandong University, Jinan, 250012, People's Republic of China. ydx0330@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold nanocages (GNCs) are a promising material that not only converts near infrared (NIR) light to heat for the ablation of tumors but also acts as a radiosensitizer. The combination of hyperthermia and radiotherapy has a synergistic effect that can lead to significant tumor cell necrosis. In the current study, we synthesized GNCs that offered the combined effects of hyperthermia and radiotherapy. This combination strategy resulted in increased tumor cell apoptosis and significant tumor tissue necrosis. We propose that GNCs can be used for clinical treatment and to potentially overcome resistance to radiotherapy by clearly increasing the antitumor effect.

Indexed as

Breast cancerGold nanocages (GNCs)HyperthermiaRadiosensitivityTargeted cancer therapy

Identifiers

PMID27255899
PMCPMC4889960

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.