ArticleNeurobiology of aging2016
Peripheral sphingolipids are associated with variation in white matter microstructure in older adults.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Population-based genome-wide association study of plasma complex lipid species.Nature communications · 2026Article
- Plasma complex lipids in relation to cortical thickness and brain volumes: results from the population-based Rhineland study.Lipids in health and disease · 2026Article
- Sex-specific relations of ceramides and white matter hyperintensities in the Rhineland study.Scientific reports · 2025Article
- White matter dysfunction in Alzheimer's disease is associated with disease-related transcriptomic signatures.Communications biology · 2025Article
- Serum lipidome associates with neuroimaging features in patients with traumatic brain injury.iScience · 2024Article
- Circulating sphingolipids and subclinical brain pathology: the cardiovascular health study.Frontiers in neurology · 2024Article
- Ceramide in cerebrovascular diseases.Frontiers in cellular neuroscience · 2023Review
- Genetics of common cerebral small vessel disease.Nature reviews. Neurology · 2022Review
- The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo.International journal of molecular sciences · 2021Article
- White Matter Injury Is Associated with Reduced Manual Dexterity and Elevated Serum Ceramides in Subjects with Cerebral Small Vessel Disease.Cerebrovascular diseases (Basel, Switzerland) · 2021Article
- Associations Between Plasma Ceramides and Cerebral Microbleeds or Lacunes.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Brain age and other bodily 'ages': implications for neuropsychiatry.Molecular psychiatry · 2019Review
- Plasma Lipid Profiling Identifies Biomarkers of Cerebral Microvascular Disease.Frontiers in neurology · 2019Article
- Plasma Sphingolipids are Associated With Gait Parameters in the Mayo Clinic Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Lipidomic characterization of extracellular vesicles in human serum.Journal of circulating biomarkersArticle
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
Abstract
Sphingolipids serve important structural and functional roles in cellular membranes and myelin sheaths. Plasma sphingolipids have been shown to predict cognitive decline and Alzheimer's disease. However, the association between plasma sphingolipid levels and brain white matter (WM) microstructure has not been examined. We investigated whether plasma sphingolipids (ceramides and sphingomyelins) were associated with magnetic resonance imaging-based diffusion measures, fractional anisotropy (FA), and mean diffusivity, 10.5 years later in 17 WM regions of 150 cognitively normal adults (mean age 67.2). Elevated ceramide species (C20:0, C22:0, C22:1, and C24:1) were associated with lower FA in multiple WM regions, including total cerebral WM, anterior corona radiata, and the cingulum of the cingulate gyrus. Higher sphingomyelins (C18:1 and C20:1) were associated with lower FA in regions such as the anterior corona radiata and body of the corpus callosum. Furthermore, lower sphingomyelin to ceramide ratios (C22:0, C24:0, and C24:1) were associated with lower FA or higher mean diffusivity in regions including the superior and posterior corona radiata. However, although these associations were significant at the a priori p < 0.05, only associations with some regional diffusion measures for ceramide C22:0 and sphingomyelin C18:1 survived correction for multiple comparisons. These findings suggest plasma sphingolipids are associated with variation in WM microstructure in cognitively normal aging.
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