ArticleNeurobiology of aging2016
Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06072963 (Combination of Intranasal Insulin With Oral Semaglutide to Improve Cognition and Cerebral Blood Flow), which is not on this map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combination of Intranasal Insulin With Oral Semaglutide to Improve Cognition and Cerebral Blood Flow: a Feasibility Study
Who cites it
51 citing papers in PubMed, 79 citations in OpenAlex.
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Major Lifetime Discrimination Exposure Accelerates Brain Microstructural Aging: Diffusion MRI Evidence From MIDUS.Biopsychosocial science and medicine · 2026Article
- Microstructural white matter alterations in dementia with lewy bodies and Alzheimer's disease: a diffusion tensor imaging and neurite orientation dispersion and density imaging study.Frontiers in aging neuroscience · 2026Article
- High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later.Neurobiology of aging · 2025Article
- Brain White Matter Changes in Non-demented Individuals with Color Discrimination Deficits and Their Association with Cognitive Impairment: A NODDI Study.Neuroscience bulletin · 2025Article
- Polyunsaturated fatty acids in lipid membranes regulate human neuronal function and amyloid-β production.iScience · 2025Article
- Aging of gray matter microstructure: A brain-wide characterization of age group differences using NODDI.Neurobiology of aging · 2025Article
- Age-related alterations in human cortical microstructure across the lifespan: Insights from high-gradient diffusion MRI.Aging cell · 2024Article
- Microstructural brain assessment in late-life depression and apathy using diffusion MRI multi-compartments models and tractometry.Scientific reports · 2024Article
- Cortical neurite microstructural correlates of time perception in healthy older adults.Heliyon · 2024Article
- Brain elastography in aging relates to fluid/solid trendlines.Physics in medicine and biology · 2024Article
- Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction and fatigue.Nature communications · 2024Article
- Role of the prefrontal cortical protease TACE/ADAM17 in neurobehavioral responses to chronic stress during adolescence.Brain and behavior · 2024Article
- Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study.CNS neuroscience & therapeutics · 2024Article
- Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health.Cerebral circulation - cognition and behavior · 2024Article
- White matter microstructural disruption in minimal hepatic encephalopathy: a neurite orientation dispersion and density imaging (NODDI) study.Neuroradiology · 2023Article
- A feasibility study of the combination of intranasal insulin with dulaglutide for cognition in older adults with metabolic syndrome at high dementia risk - Study rationale and design.Mechanisms of ageing and development · 2023Article
- Brain Microstructural Changes in Patients with Amnestic mild Cognitive Impairment : Detected by Neurite Orientation Dispersion and Density Imaging (NODDI) Combined with Machine Learning.Clinical neuroradiology · 2023Article
- High cortical iron is associated with the disruption of white matter tracts supporting cognitive function in healthy older adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Unique information from common diffusion MRI models about white-matter differences across the human adult lifespan.Imaging neuroscience (Cambridge, Mass.) · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Human aging is accompanied by progressive changes in executive function and memory, but the biological mechanisms underlying these phenomena are not fully understood. Using neurite orientation dispersion and density imaging, we sought to examine the relationship between age, cellular microstructure, and neuropsychological scores in 116 late middle-aged, cognitively asymptomatic participants. Results revealed widespread increases in the volume fraction of isotropic diffusion and localized decreases in neurite density in frontal white matter regions with increasing age. In addition, several of these microstructural alterations were associated with poorer performance on tests of memory and executive function. These results suggest that neurite orientation dispersion and density imaging is capable of measuring age-related brain changes and the neural correlates of poorer performance on tests of cognitive functioning, largely in accordance with published histological findings and brain-imaging studies of people of this age range. Ultimately, this study sheds light on the processes underlying normal brain development in adulthood, knowledge that is critical for differentiating healthy aging from changes associated with dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.