ArticleNeurobiology of aging2016
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Review
- Sirtuins mediate the reduction of age-related oxidative damage in the cochlea under a cocoa-rich diet.GeroScience · 2026Article
- AAV-mediated surtuin 1 overexpression in the cochlear inner hair cells protects ribbon synapses of D-galactose-induced aging mice.Molecular biology reports · 2026Article
- Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Epigenetic Modifications in Sensorineural Hearing Loss: Protective Mechanisms and Therapeutic Potential.Current medical science · 2025Review
- Review
- Article
- Roles of Sirtuins in Hearing Protection.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Fatty acid binding protein type 7 deficiency preserves auditory function in noise-exposed mice.Scientific reports · 2023Article
- Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway.Stem cell research & therapy · 2023Article
- Cocoa Polyphenol Extract Inhibits Cellular Senescence via Modulation of SIRT1 and SIRT3 in Auditory Cells.Nutrients · 2023Article
- The sirtuin family in health and disease.Signal transduction and targeted therapy · 2022Review
- Potential therapeutic role of SIRT1 in age- related hearing loss.Frontiers in molecular neuroscience · 2022Review
- Protective Effects of NFrontiers in cellular neuroscience · 2021Article
- Article
- Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss.NPJ aging and mechanisms of disease · 2020Article
- Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan.Experimental gerontology · 2020Article
- Presbycusis: An Update on Cochlear Mechanisms and Therapies.Journal of clinical medicine · 2020Review
- Short-term NADNPJ aging and mechanisms of disease · 2020Article
- Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice.BMC research notes · 2019Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Hearing gradually declines with age in both animals and humans, and this condition is known as age-related hearing loss (AHL). Here, we investigated the effects of deficiency of Sirt1, a member of the mammalian sirtuin family, on age-related cochlear pathology and associated hearing loss in C57BL/6 mice, a mouse model of early-onset AHL. Sirt1 deficiency reduced age-related oxidative damage of cochlear hair cells and spiral ganglion neurons and delayed the early onset of AHL. In cultured mouse inner ear cell lines, Sirt1 knockdown increased cell viability under oxidative stress conditions, induced nuclear translocation of Foxo3a, and increased acetylation status of Foxo3a. This resulted in increased activity of the antioxidant enzyme catalase. In young wild-type mice, both Sirt1 and Foxo3a proteins resided in the cytoplasm of the supporting cells within the organ of Corti of the cochlea. Therefore, our findings suggest that SIRT1 promotes early-onset AHL through suppressing FOXO3a-mediated oxidative stress resistance in the cochlea of C57BL/6 mice.
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