ArticleNeurobiology of aging2016
Differential effects of Cdh23(753A) on auditory and vestibular functional aging in C57BL/6J mice.
Article in Neurobiology of aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Conserved trajectories of age-related thigmotaxis across insects and mammals reveal the house cricket as a scalable model for behavioral aging.GeroScience · 2026Article
- Brimonidine Therapy for Protection From Noise-Induced Hearing Loss.Aging cell · 2026Article
- Limiting Hearing Loss in Transgenic Mouse Models.eNeuro · 2025Article
- Functional, Morphological and Molecular Changes Reveal the Mechanisms Associated with Age-Related Vestibular Loss.Biomolecules · 2023Article
- mTORC2 regulates auditory hair cell structure and function.iScience · 2023Article
- Molecular and Functional Changes to Postsynaptic Cholinergic Signaling in the Vestibular Sensory Organs of Aging C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- An integrated workflow for 2D and 3D posture analysis during vestibular system testing in mice.Frontiers in neurology · 2023Article
- Age-dependent structural reorganization of utricular ribbon synapses.Frontiers in cell and developmental biology · 2023Article
- Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice.Biomedicines · 2022Article
- The Differentiation Status of Hair Cells That Regenerate Naturally in the Vestibular Inner Ear of the Adult Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes.Frontiers in neuroscience · 2021Review
- Developmental GAD2 Expression Reveals Progenitor-like Cells with Calcium Waves in Mammalian Crista Ampullaris.iScience · 2020Article
- Functional organization of mouse primary auditory cortex in adult C57BL/6 and F1 (CBAxC57) mice.Scientific reports · 2020Article
- Role of melatonin in prevention of age-related hearing loss.PloS one · 2020Article
- Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions.Scientific reports · 2019Article
- Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice.Frontiers in aging neuroscience · 2019Article
- Effects of 3,3'-Iminodipropionitrile on Hair Cell Numbers in Cristae of CBA/CaJ and C57BL/6J Mice.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide.Human molecular genetics · 2017Article
- Development and regeneration of vestibular hair cells in mammals.Seminars in cell & developmental biology · 2017Review
- Gfi1Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The C57BL/6J (B6) mouse strain carries a cadherin 23 mutation (Cdh23(753A), also known as Ahl), which affects inner ear structures and results in age-related hearing loss. The B6.CAST strain harbors the wild type Cdh23 gene, and hence, the influence of Ahl is absent. The purpose of the present study was to characterize the effect of age and gender on gravity receptor function in B6 and B6.CAST strains and to compare functional aging between auditory and vestibular modalities. Auditory sensitivity declined at significantly faster rates than gravity receptor sensitivity for both strains. Indeed, vestibular functional aging was minimal for both strains. The comparatively smaller loss of macular versus cochlear sensitivity in both the B6 and B6.CAST strains suggests that the contribution of Ahl to the aging of the vestibular system is minimal, and thus very different than its influence on aging of the auditory system. Alternatively, there exist unidentified genes or gene modifiers that serve to slow the degeneration of gravity receptor structures and maintain gravity receptor sensitivity into advanced age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.