Evidence map›Paper›PMID 27255706›Full record

ArticleCerebellum (London, England)2017

Diffusion Tensor Tractography of the Cerebellar Peduncles in Prematurely Born 7-Year-Old Children.

Eilon Shany, Terrie E Inder, Sharon Goshen, Iris Lee, Jeffrey J Neil, Christopher D Smyser, Lex W Doyle, Peter J Anderson, Joshua S Shimony

Open access · greenAbstract read
In one paragraph

Article in Cerebellum (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

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  14. Clinical application of advanced MR methods in children: points to consider.Annals of clinical and translational neurology · 2018
    Review
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  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Eilon ShanyDepartment of Neonatology, Soroka Medical Center, P.O. Box 151, 84101, Beer Sheva, Israel. eshany@bgu.ac.il.
Terrie E InderDepartment of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sharon GoshenFaculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Iris LeeDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Jeffrey J NeilDepartment of Neurology, Boston Children's Hospital, Boston, MA, USA.
Christopher D SmyserDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Lex W DoyleDepartment of Obstetrics and Gynaecology, The Royal Women's Hospital, Melbourne, Australia.
Peter J AndersonClinical Sciences, Murdoch Children's Research Institute, Melbourne, Australia.
Joshua S ShimonyMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Mallinckrodt (United States) · USMurdoch Children's Research Institute · AUBen-Gurion University of the Negev · ILBoston Children's Hospital · USBrigham and Women's Hospital · USSoroka Medical Center · ILWashington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
Neurobehavioral Impairments in Preterm Children - A Longitudinal MR StudyR01HD058056 · NICHD · WASHINGTON UNIVERSITY · PI INDER, TERRIE E · 2008 to 2011
$1.9M
PREDICTING CHILDHOOD OUTCOMES IN PRETERM INFANTS USING CEREBRAL CONNECTIVITYK02NS089852 · NINDS · WASHINGTON UNIVERSITY · PI SMYSER, CHRISTOPHER DANIEL · 2014 to 2018
$848k
NCATS NIH HHS UL1 TR000448NICHD NIH HHS R01 HD058056NICHD NIH HHS U54 HD087011NINDS NIH HHS K02 NS089852
6 · The paper itself

Abstract

The objective of this study was to correlate neurodevelopmental outcome of preterm-born children and their perinatal clinical and imaging characteristics with diffusion magnetic resonance imaging (MRI) measures of the three cerebellar peduncles at age 7. Included in this prospective longitudinal study were 140 preterm-born children (<30 weeks gestation) who underwent neurodevelopmental assessment (IQ, motor, language, working memory) and diffusion-weighted imaging (DWI) at age 7 years. White matter tracts in the superior, middle, and inferior cerebellar peduncles were delineated using regions of interest drawn on T2-weighted images and fractional anisotropy (FA) maps. Diffusion measures (mean diffusivity (MD) and FA) and tract volumes were calculated. Linear regression was used to assess relationships with outcome. The severity of white matter injury in the neonatal period was associated with lower FA in the right superior cerebellar peduncle (SCP) and lower tract volumes of both SCPs and middle cerebellar peduncles (MCPs). In the MCP, higher IQ was associated with lower MD in the whole group and higher FA in right-handed children. In the SCP, lower motor scores were associated with higher MD and higher language scores were associated with higher FA. These associations remained significant in multivariable models. This study adds to the body of literature detailing the importance of cerebellar involvement in cognitive function related to reciprocal connections with supratentorial structures.

Indexed as

CerebellumChildDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleFollow-Up StudiesHumansInfant, PrematureIntelligenceIntelligence TestsLanguageLanguage TestsLinear ModelsLongitudinal StudiesMaleMotor ActivityCerebellumMagnetic resonance imagingNeurodevelopmental outcomePremature infants

Identifiers

PMID27255706
PMCPMC5136350
OpenAlexW2416522317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.