ArticleBMC complementary and alternative medicine2016
Phytochemical profiles and inhibitory effects of Tiger Milk mushroom (Lignosus rhinocerus) extract on ovalbumin-induced airway inflammation in a rodent model of asthma.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Effectiveness of tiger milk mushroom (Lignosus rhinocerus) on asthma: a systematic review.BMC pulmonary medicine · 2026Pooled it
- Genome mining and functional characterization of four type I sesquiterpene synthases from the Tiger Milk Mushroom Lignosus rhinocerus.Natural products and bioprospecting · 2026Article
- Cellular Core/Sheath Filaments with Thermoresponsive Vacuum Cavities for Prolonged Passive Temperature-Adaptive Thermoregulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Chemical Analysis of SU-Eohyeol Pharmacopuncture and ItsInternational journal of medical sciences · 2024Article
- Lignosus rhinocerotis extract ameliorates airway inflammation and remodelling via attenuation of TGF-β1 and Activin A in a prolonged induced allergic asthma model.Scientific reports · 2023Article
- Potential Hemostatic and Wound Healing Effects of Thermoresponsive Wound Dressing Gel Loaded withGels (Basel, Switzerland) · 2023Article
- The Wound Healing Potential ofMycobiology · 2023Review
- In vivo toxicity of bioreactor-grown biomass and exopolysaccharides from Malaysian tiger milk mushroom mycelium for potential future health applications.Scientific reports · 2021Article
- Volatile Profiling ofFoods (Basel, Switzerland) · 2021Article
- Effect of tiger milk mushroom (Lignosus rhinocerus) supplementation on respiratory health, immunity and antioxidant status: an open-label prospective study.Scientific reports · 2021Article
- Extracts of the Tiger Milk Mushroom (Pharmaceuticals (Basel, Switzerland) · 2021Article
- Article
- HIV-1 protease and reverse transcriptase inhibition by tiger milk mushroom (Journal of traditional and complementary medicine · 2020Article
- Intranasal administration ofExperimental and therapeutic medicine · 2019Article
- Clinical efficacy of recombinant human latrophilin 3 antibody in the treatment of pediatric asthma.Experimental and therapeutic medicine · 2018Article
- Comparative nutritional and mycochemical contents, biological activities and LC/MS screening of tuber from new recipe cultivation technique with wild type tuber of tiger's milk mushroom of species Lignosus rhinocerus.World journal of microbiology & biotechnology · 2017Article
- A Status Review of the Bioactive Activities of Tiger Milk MushroomFrontiers in pharmacology · 2017Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLignosus rhinocerus (L. rhinocerus), which is known locally as Tiger Milk mushroom, is traditionally used in the treatment of asthma by indigenous communities in Malaysia. However, to date, its efficacy on asthma has not been confirmed by scientific studies and there is also sparse information available on its active constituents. In this study, the volatile constituent of L. rhinocerus hot water extract was investigated using gas chromatography mass spectrometry (GC-MS). The potential effects of L. rhinocerus extract for anti-asthmatic activity was further investigated on ovalbumin (OVA)-sensitized asthmatic Sprague Dawley rats.
methodsSequential extraction using five solvents (petroleum ether, diethyl ether, hexane, ethyl acetate and methanol) was conducted prior to GC-MS analysis. Male Sprague Dawley rats were divided into the following four groups of five animals each: 1) normal rats, 2) sensitization plus OVA-challenged rats 3) sensitization plus OVA-challenged with L. rhinocerus treatment and 4) sensitization plus OVA-challenged with dexamethasone treatment. The levels of immunoglobulin E (IgE) in the serum and T-helper 2 cytokines, including interleukin (IL)-4, IL-5 and IL-13, in bronchoalveolar lavage fluid (BALF), as well as eosinophil infiltration in the lungs, were investigated.
resultsGC-MS analysis revealed the presence of five main groups (alkane, fatty acids, benzene, phenol and dicarboxylic acid) with a total of 18 constituents. Linoleic acid (21.35 %), octadecane (11.82 %) and 2,3-dihydroxypropyl elaidate (10.47 %) were present in high amounts. The extract significantly ameliorated the increase in total IgE in serum and IL-4, IL-5 and IL-13 levels in BALF and also effectively suppressed eosinophils numbers in BALF while attenuating eosinophil infiltrations in the lungs.
conclusionL. rhinocerus hot water extract has the potential to be used as an alternative for the treatment of acute asthma.
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