ArticleScientific reports2016
Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 82 citations in OpenAlex.
- Review
- Article
- Paternal Malnutrition has Organ-Specific Intergenerational Effects on Mitochondrial Function and Oxidative Stress Induced DNA Damage in Male Mouse Offspring.Molecular nutrition & food research · 2026Article
- Review
- Transgenerational Impact of Environmental Change.Advances in experimental medicine and biology · 2026Review
- The Functional Role of Polyphenols Across the Human Lifespan.International journal of molecular sciences · 2025Review
- Beyond Genes: Mechanistic and Epidemiological Insights into Paternal Environmental Influence on Offspring Health.Current environmental health reports · 2025Review
- Paternal and/or Maternal Blackberry (Antioxidants (Basel, Switzerland) · 2025Article
- Association of Paternal BMI and Diet During Pregnancy with Offspring Birth Measures: The STEPS Study.Nutrients · 2025Article
- The Impact of Parental Preconception Nutrition, Body Weight, and Exercise Habits on Offspring Health Outcomes: A Narrative Review.Nutrients · 2024Review
- Preconceptional paternal caloric restriction of high-fat diet-induced obesity in Wistar rats dysregulates the metabolism of their offspring via AMPK/SIRT1 pathway.Lipids in health and disease · 2024Article
- Influence of maternal folate depletion on Art3 DNA methylation in the murine adult brain; potential consequences for brain and neurocognitive health.Mutagenesis · 2024Article
- Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring.Nature communications · 2024Article
- Review
- Divergent planes of nutrition in mature rams influences body composition, hormone and metabolite concentrations, and offspring birth measurements, but not semen characteristics or offspring growth.Journal of animal science · 2024Article
- Influence of sire plane of nutrition and targeted body weight gain on ewe lamb growth, glucose metabolism, and ovarian reserve.Journal of animal science · 2024Article
- Natural products for managing metabolic syndrome: a scoping review.Frontiers in pharmacology · 2024Article
- Sperm RNA Payload: Implications for Intergenerational Epigenetic Inheritance.International journal of molecular sciences · 2023Review
- Effects of paternal methionine supplementation on sperm DNA methylation and embryo transcriptome in sheep.Environmental epigenetics · 2023Article
- Transgenerational inheritance and its modulation by environmental cues.Current topics in developmental biology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an ever increasing body of evidence that demonstrates that paternal over-nutrition prior to conception programs impaired metabolic health in offspring. Here we examined whether paternal under-nutrition can also program impaired health in offspring and if any detrimental health outcomes in offspring could be prevented by micronutrient supplementation (vitamins and antioxidants). We discovered that restricting the food intake of male rodents reduced their body weight, fertility, increased sperm oxidative DNA lesions and reduced global sperm methylation. Under-nourished males then sired offspring with reduced postnatal weight and growth but somewhat paradoxically increased adiposity and dyslipidaemia, despite being fed standard chow. Paternal vitamin/antioxidant food fortification during under-nutrition not only normalised founder oxidative sperm DNA lesions but also prevented early growth restriction, fat accumulation and dyslipidaemia in offspring. This demonstrates that paternal under-nutrition reduces postnatal growth but increases the risk of obesity and metabolic disease in the next generation and that micronutrient supplementation during this period of under-nutrition is capable of restoring offspring metabolic health.
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Registered trials
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