ArticleScientific reports2016
The roles of RelA/(p)ppGpp in glucose-starvation induced adaptive response in the zoonotic Streptococcus suis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Bone cells modulateBiofilm · 2026Article
- RelA-mediated (p)ppGpp accumulation links glucose starvation to peptidoglycan synthesis arrest and spherical morphogenesis via PBP2x and FtsX inJournal of bacteriology · 2026Article
- Iron-manganese superoxide dismutases are primarily responsible for antioxidative responses, antibiotic tolerance, and virulence of Salmonella Pullorum.Poultry science · 2026Article
- Evaluation of serine protein kinase HPrK as an antibacterial target in gram-positive bacteria and mycoplasmas.Microbiology spectrum · 2026Article
- RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation inMicrobiology (Reading, England) · 2024Article
- RelQ-mediated alarmone signaling regulates growth, sporulation, and stress-induced biofilm formation inbioRxiv : the preprint server for biology · 2024Article
- Pathogenicity and identification of host adaptation genes of the avian pathogenicFrontiers in cellular and infection microbiology · 2024Article
- Rifampicin-resistant RpoB S522L Vibrio vulnificus exhibits disturbed stress response and hypervirulence traits.MicrobiologyOpen · 2023Article
- Protein-Ligand Interactions in Scarcity: The Stringent Response from Bacteria to Metazoa, and the Unanswered Questions.International journal of molecular sciences · 2023Review
- How Streptococcus suis escapes antibiotic treatments.Veterinary research · 2022Review
- Exogenous glycogen utilization effects the transcriptome and pathogenicity ofFrontiers in cellular and infection microbiology · 2022Article
- Involvement of Various Enzymes in the Physiology and Pathogenesis ofVeterinary sciences · 2020Review
- The (p)ppGpp Synthetase RSH Mediates Stationary-Phase Onset and Antibiotic Stress Survival in Clostridioides difficile.Journal of bacteriology · 2020Article
- Regulation of (p)ppGpp and Its Homologs on Environmental Adaptation, Survival, and Pathogenicity of Streptococci.Frontiers in microbiology · 2020Review
- Carbon Starvation Induces the Expression of PprB-Regulated Genes in Pseudomonas aeruginosa.Applied and environmental microbiology · 2019Article
- Determination of the Gene Regulatory Network of a Genome-Reduced Bacterium Highlights Alternative Regulation Independent of Transcription Factors.Cell systems · 2019Article
- Transcriptomic Changes ofFrontiers in cellular and infection microbiology · 2019Article
- Increased Mortality in Mice following Immunoprophylaxis Therapy with High Dosage of Nicotinamide inInfection and immunity · 2019Article
- Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis.Microbiology (Reading, England) · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The (p)ppGpp signal molecules play a central role in the stringent response (SR) to adapt to nutrient starvation in bacteria, yet the carbohydrate starvation induced adaptive response and the roles of SR in this response is not well characterized, especially in Gram-positives. Here, two (p)ppGpp synthetases RelA and RelQ are identified in Streptococcus suis, an important emerging zoonotic Gram-positive bacterium, while only RelA is functional under glucose starvation. To characterize the roles of RelA/(p)ppGpp in glucose starvation response in S. suis, the growth curves and transcriptional profiles were compared between the mutant strain ΔrelA [a (p)ppGpp(0) strain under glucose starvation] and its parental strain SC-19 [(p)ppGpp(+)]. The results showed great difference between SC-19 and ΔrelA on adaptive responses when suffering glucose starvation, and demonstrated that RelA/(p)ppGpp plays important roles in adaptation to glucose starvation. Besides the classic SR including inhibition of growth and related macromolecular synthesis, the extended adaptive response also includes inhibited glycolysis, and carbon catabolite repression (CCR)-mediated carbohydrate-dependent metabolic switches. Collectively, the pheno- and genotypic characterization of the glucose starvation induced adaptive response in S. suis makes a great contribution to understanding better the mechanism of SR.
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