ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03700671 (The Effects of Low-Volume High Intensity Interval Training and Circuit Training on Maximal Oxygen Uptake), which is not on this map. Cited by 90 papers, 16 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Low-Volume High Intensity Interval Training and Circuit Training on Maximal Oxygen Uptake
Who cites it
90 citing papers in PubMed, 16 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Optimising Exercise Prescription: A Meta-Analysis Examining the Dose Response of Exercise Duration on Cardiorespiratory Fitness Following HIIT and MICT.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- High-intensity interval training versus moderate-intensity continuous training for polycystic ovary syndrome: a meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2025Pooled it
- Exercise interventions for patients with heart failure: an evidence map.Frontiers in sports and active living · 2025Pooled it
- Efficacy of Interval Training in Improving Body Composition and Adiposity in Apparently Healthy Adults: An Umbrella Review with Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Effects of high-intensity interval training versus moderate-intensity continuous training on vascular function among individuals with overweight and obesity-a systematic review.International journal of obesity (2005) · 2024Pooled it
- The effects of high-intensity interval training versus moderate-intensity continuous training on athletes' aerobic endurance performance parameters.European journal of applied physiology · 2024Pooled it
- Pooled it
- Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023Pooled it
- The Benefits of Physical Activity for People with Obesity, Independent of Weight Loss: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- What is the impact of aerobic fitness and movement interventions on low-flow-mediated vasoconstriction? A systematic review of observational and intervention studies.Vascular medicine (London, England) · 2022Pooled it
- The impact of high-intensity interval training on vascular function in adults: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Effect of Exercise Training on Body Composition and Inflammatory Cytokine Levels in Overweight and Obese Individuals: A Systematic Review and Network Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Comparative Effectiveness of High-Intensity Interval Training and Moderate-Intensity Continuous Training for Cardiometabolic Risk Factors and Cardiorespiratory Fitness in Childhood Obesity: A Meta-Analysis of Randomized Controlled Trials.Frontiers in physiology · 2020Pooled it
- Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and/or obesity: A meta-analysis.PloS one · 2019Pooled it
- Short-Term (<8 wk) High-Intensity Interval Training in Diseased Cohorts.Medicine and science in sports and exercise · 2018Pooled it
- Effect of High-Intensity Interval Training on Total, Abdominal and Visceral Fat Mass: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Aquatic High-Intensity Interval Training Improves Vascular Function, Whereas Aquatic Moderate-Intensity Continuous Training Lowers Resting Heart Rate in Overweight and Obese Young Adults: A Randomized Controlled Trial.Journal of sports science & medicine · 2025Trial
- Effects of different training modes on hemodynamics and vascular endothelial function in young obese adults.Scientific reports · 2025Trial
- Comparison of high-intensity interval training and moderate-intensity continuous training on cardiopulmonary function, cardiac autonomic function and vascular function in adolescent boys with obesity: A randomized controlled trial.European journal of sport science · 2024Trial
- Effects of Omega-3 Supplementation on the Delayed Onset Muscle Soreness after Cycling High Intensity Interval Training in Overweight or Obese Males.Journal of sports science & medicine · 2024Trial
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We hypothesized that high-intensity interval training (HIIT) would be more effective than moderate-intensity continuous training (MICT) at improving endothelial function and maximum oxygen uptake (V̇o2 max) in obese adults. Eighteen participants [35.1 ± 8.1 (SD) yr; body mass index = 36.0 ± 5.0 kg/m(2)] were randomized to 8 wk (3 sessions/wk) of either HIIT [10 × 1 min, 90-95% maximum heart rate (HRmax), 1-min active recovery] or MICT (30 min, 70-75% HRmax). Brachial artery flow-mediated dilation (FMD) increased after HIIT (5.13 ± 2.80% vs. 8.98 ± 2.86%, P = 0.02) but not after MICT (5.23 ± 2.82% vs. 3.05 ± 2.76%, P = 0.16). Resting artery diameter increased after MICT (3.68 ± 0.58 mm vs. 3.86 ± 0.58 mm, P = 0.02) but not after HIIT (4.04 ± 0.70 mm vs. 4.09 ± 0.70 mm; P = 0.63). There was a significant (P = 0.02) group × time interaction in low flow-mediated constriction (L-FMC) between MICT (0.63 ± 2.00% vs. -2.79 ± 3.20%; P = 0.03) and HIIT (-1.04 ± 4.09% vs. 1.74 ± 3.46%; P = 0.29). V̇o2 max increased (P < 0.01) similarly after HIIT (2.19 ± 0.65 l/min vs. 2.64 ± 0.88 l/min) and MICT (2.24 ± 0.48 l/min vs. 2.55 ± 0.61 l/min). Biomarkers of cardiovascular risk and endothelial function were unchanged. HIIT and MICT produced different vascular adaptations in obese adults, with HIIT improving FMD and MICT increasing resting artery diameter and enhancing L-FMC. HIIT required 27.5% less total exercise time and ∼25% less energy expenditure than MICT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.