Evidence map›Paper›PMID 27255484›Full record

ArticlePlant physiology2016

The ERF11 Transcription Factor Promotes Internode Elongation by Activating Gibberellin Biosynthesis and Signaling.

Xin Zhou, Zhong-Lin Zhang, Jeongmoo Park, Ludmila Tyler, Jikumaru Yusuke, Kai Qiu, Edward A Nam, Shelley Lumba, Darrell Desveaux, Peter McCourt and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
  2. CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  12. Deciphering the regulatory network of lignocellulose biosynthesis in bread wheat through genome-wide association studies.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 4 countries.

Xin ZhouDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).
Zhong-Lin ZhangDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).
Jeongmoo ParkDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).ORCID 0000-0003-2555-5929
Ludmila TylerDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).
Jikumaru YusukeDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).
Kai QiuDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).
Edward A NamDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).ORCID 0000-0002-7950-7001
Shelley LumbaDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).
Darrell DesveauxDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).
Peter McCourtDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).
Yuji KamiyaDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.).ORCID 0000-0003-4415-520X
Tai-Ping SunDepartment of Biology, Duke University, Durham, North Carolina 27705 (X.Z., Z.-L.Z., L.T., J.P., E.A.N., T.-p.S.); RIKEN Plant Science Center, Yokohama, Kanagawa 230-0045, Japan (J.Y., Y.K.); Department of Cell and Systems Biology, University of Toronto, Ontario M5S 3B2, Canada (S.L., D.D., P.M.); Centre for the Analysis of Genome Evolution and Function, University of Toronto, Ontario M5S 3B2, Canada (D.D.); andState Key Laboratory of Genetic Engineering and Fudan Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (K.Q.) tps@duke.edu.
Duke University · USUniversity of Toronto · CA

Funding

Structure and Function Analyses of DELLA Interacting Proteins in ArabidopsisR01GM100051 · NIGMS · DUKE UNIVERSITY · PI SUN, TAI-PING · 2012 to 2021
$2.4M
NIGMS NIH HHS R01 GM100051
6 · The paper itself

Abstract

The phytohormone gibberellin (GA) plays a key role in promoting stem elongation in plants. Previous studies show that GA activates its signaling pathway by inducing rapid degradation of DELLA proteins, GA signaling repressors. Using an activation-tagging screen in a reduced-GA mutant ga1-6 background, we identified AtERF11 to be a novel positive regulator of both GA biosynthesis and GA signaling for internode elongation. Overexpression of AtERF11 partially rescued the dwarf phenotype of ga1-6 AtERF11 is a member of the ERF (ETHYLENE RESPONSE FACTOR) subfamily VIII-B-1a of ERF/AP2 transcription factors in Arabidopsis (Arabidopsis thaliana). Overexpression of AtERF11 resulted in elevated bioactive GA levels by up-regulating expression of GA3ox1 and GA20ox genes. Hypocotyl elongation assays further showed that overexpression of AtERF11 conferred elevated GA response, whereas loss-of-function erf11 and erf11 erf4 mutants displayed reduced GA response. In addition, yeast two-hybrid, coimmunoprecipitation, and transient expression assays showed that AtERF11 enhances GA signaling by antagonizing the function of DELLA proteins via direct protein-protein interaction. Interestingly, AtERF11 overexpression also caused a reduction in the levels of another phytohormone ethylene in the growing stem, consistent with recent finding showing that AtERF11 represses transcription of ethylene biosynthesis ACS genes. The effect of AtERF11 on promoting GA biosynthesis gene expression is likely via its repressive function on ethylene biosynthesis. These results suggest that AtERF11 plays a dual role in promoting internode elongation by inhibiting ethylene biosynthesis and activating GA biosynthesis and signaling pathways.

Indexed as

Signal TransductionArabidopsisArabidopsis ProteinsEthylenesGene Expression Regulation, PlantGibberellinsModels, BiologicalPlant StemsPromoter Regions, GeneticProtein BindingRepressor ProteinsRNA, MessengerTranscription FactorsTranscription, GeneticArabidopsis ProteinsERF11 protein, ArabidopsisethyleneEthylenesGibberellinsRepressor ProteinsRNA, MessengerTranscription Factors

Identifiers

PMID27255484
PMCPMC4972265
OpenAlexW2489287264

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.