Evidence map›Paper›PMID 27255389›Full record

ReviewCurrent oncology reports2016

The Gut Microbiome and Obesity.

George Kunnackal John, Gerard E Mullin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 3 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 3 syntheses or guidelines pooled it, 298 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Probiotics for preventing gestational diabetes.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Review
  9. Hydroxy-α-Sanshools FromFood science & nutrition · 2026
    Article
  10. Review
  11. Synergistic effect of a naturally derivedBioscience of microbiota, food and health · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Foods (Basel, Switzerland) · 2025
    Article

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

George Kunnackal JohnDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Gerard E MullinDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD, 21287, USA. gmullin1@jhmi.edu.
Johns Hopkins Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome consists of trillions of bacteria which play an important role in human metabolism. Animal and human studies have implicated distortion of the normal microbial balance in obesity and metabolic syndrome. Bacteria causing weight gain are thought to induce the expression of genes related to lipid and carbohydrate metabolism thereby leading to greater energy harvest from the diet. There is a large body of evidence demonstrating that alteration in the proportion of Bacteroidetes and Firmicutes leads to the development of obesity, but this has been recently challenged. It is likely that the influence of gut microbiome on obesity is much more complex than simply an imbalance in the proportion of these phyla of bacteria. Modulation of the gut microbiome through diet, pre- and probiotics, antibiotics, surgery, and fecal transplantation has the potential to majorly impact the obesity epidemic.

Indexed as

Gastrointestinal MicrobiomeAnimalsHumansObesityProbioticsBacteroidetesDietFirmicutesMicrobial balanceMicrobiomeMicrobiotaObesityPrebioticProbiotic

Identifiers

PMID27255389
OpenAlexW2413207665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.