ArticleToxicological sciences : an official journal of the Society of Toxicology2016
From the Cover: Disease-Induced Disparities in Formation of the Nanoparticle-Biocorona and the Toxicological Consequences.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Protective Effect of Silver Nanoparticles Against Cytosine Arabinoside Genotoxicity: An In Vivo Micronucleus Assay.International journal of environmental research and public health · 2024Article
- Review
- Biocorona-induced modifications in engineered nanomaterial-cellular interactions impacting biomedical applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models.Frontiers in bioengineering and biotechnology · 2020Review
- An Integrative Proteomic/Lipidomic Analysis of the Gold Nanoparticle Biocorona in Healthy and Obese Conditions.Applied in vitro toxicology · 2019Article
- Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment.Nanoscale research letters · 2018Article
- Experimental challenges regarding the in vitro investigation of the nanoparticle-biocorona in disease states.Toxicology in vitro : an international journal published in association with BIBRA · 2018Article
- Altered formation of the iron oxide nanoparticle-biocorona due to individual variability and exercise.Environmental toxicology and pharmacology · 2018Article
- Immune responses to engineered nanomaterials: current understanding and challenges.Current opinion in toxicology · 2018Article
- In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- Variations in biocorona formation related to defects in the structure of single walled carbon nanotubes and the hyperlipidemic disease state.Scientific reports · 2017Article
- The biocorona: a challenge for the biomedical application of nanoparticles.Nanotechnology reviews · 2017Article
- Contribution of engineered nanomaterials physicochemical properties to mast cell degranulation.Scientific reports · 2017Article
- Personalized protein corona on nanoparticles and its clinical implications.Biomaterials science · 2017Review
- Pulmonary iron oxide (FeHuman & experimental toxicologyArticle
- Formation of a protein corona influences the biological identity of nanomaterials.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Nanoparticle (NP) association with macromolecules in a physiological environment forms a biocorona (BC), which alters NP distribution, activity, and toxicity. While BC formation is dependent on NP physicochemical properties, little information exists on the influence of the physiological environment. Obese individuals and those with cardiovascular disease exist with altered serum chemistry, which is expected to influence BC formation and NP toxicity. We hypothesize that a BC formed on NPs following incubation in hyperlipidemic serum will result in altered NP-BC protein content, cellular association, and toxicity compared to normal serum conditions. We utilized Fe3O4 NPs, which are being developed as MRI contrast and tumor targeting agents to test our hypothesis. We used rat aortic endothelial cells (RAECs) within a dynamic flow in vitro exposure system to more accurately depict the in vivo environment. A BC was formed on 20nm PVP-suspended Fe3O4 NPs following incubation in water, 10% normal or hyperlipidemic rat serum. Addition of BCs resulted in increased hydrodynamic size and decreased surface charge. More cholesterol associated with Fe3O4 NPs after incubation in hyperlipidemic as compared with normal serum. Using quantitative proteomics, we identified unique differences in BC protein components between the 2 serum types. Under flow conditions, formation of a BC from both serum types reduced RAECs association of Fe3O4 NPs. Addition of BCs was found to exacerbate RAECs inflammatory gene responses to Fe3O4 NPs (Fe3O4-hyperlipidemic > Fe3O4-normal > Fe3O4) including increased expression of IL-6, TNF-α, Cxcl-2, VCAM-1, and ICAM-1. Overall, these findings demonstrate that disease-induced variations in physiological environments have a significant impact NP-BC formation, cellular association, and cell response.
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