ArticleMolecular and cellular biology1989
An internal regulatory element controls troponin I gene expression.
Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 103 citations in OpenAlex.
- Identification of novel nucleotide sequence variations in an extended region of the bovine leptin gene (Archives animal breeding · 2020Article
- Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.American journal of physiology. Cell physiology · 2009Article
- The ups and downs of gene regulation by electrical activity in skeletal muscles.Journal of muscle research and cell motility · 2009Review
- Activity-dependent repression of muscle genes by NFAT.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.Gene expression patterns : GEP · 2007Article
- Novel haplotype description and structural background of the eventual functional significance of the barley beta-amylase gene intron III rearrangements.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2006Article
- Large deletions within the first intron in VRN-1 are associated with spring growth habit in barley and wheat.Molecular genetics and genomics : MGG · 2005Article
- Imaging transcription in vivo: distinct regulatory effects of fast and slow activity patterns on promoter elements from vertebrate troponin I isoform genes.The Journal of physiology · 2005Article
- Transcription of Drosophila troponin I gene is regulated by two conserved, functionally identical, synergistic elements.Molecular biology of the cell · 2004Article
- Molecular dissection of DNA sequences and factors involved in slow muscle-specific transcription.Molecular and cellular biology · 2001Article
- Critical regulatory domains in intron 2 of a porcine sarcomeric myosin heavy chain gene.Journal of muscle research and cell motility · 2000Article
- Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements.Molecular and cellular biology · 1999Article
- The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function.Genetics · 1999Article
- The human pH aldolase A promoter directs widespread but muscle-predominant expression in transgenic mice.Transgenic research · 1998Article
- Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4.The Biochemical journal · 1997Article
- A minimal regulatory region maintains constitutive expression of the max gene.Molecular and cellular biology · 1997Article
- Common core sequences are found in skeletal muscle slow- and fast-fiber-type-specific regulatory elements.Molecular and cellular biology · 1996Article
- Novel muscle-specific enhancer sequences upstream of the cardiac actin gene.Molecular and cellular biology · 1994Article
- A novel myogenic regulatory circuit controls slow/cardiac troponin C gene transcription in skeletal muscle.Molecular and cellular biology · 1994Article
- cis-acting sequences of the rat troponin I slow gene confer tissue- and development-specific transcription in cultured muscle cells as well as fiber type specificity in transgenic mice.Molecular and cellular biology · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During skeletal myogenesis, approximately 20 contractile proteins and related gene products temporally accumulate as the cells fuse to form multinucleated muscle fibers. In most instances, the contractile protein genes are regulated transcriptionally, which suggests that a common molecular mechanism may coordinate the expression of this diverse and evolutionarily unrelated gene set. Recent studies have examined the muscle-specific cis-acting elements associated with numerous contractile protein genes. All of the identified regulatory elements are positioned in the 5'-flanking regions, usually within 1,500 base pairs of the transcription start site. Surprisingly, a DNA consensus sequence that is common to each contractile protein gene has not been identified. In contrast to the results of these earlier studies, we have found that the 5'-flanking region of the quail troponin I (TnI) gene is not sufficient to permit the normal myofiber transcriptional activation of the gene. Instead, the TnI gene utilizes a unique internal regulatory element that is responsible for the correct myofiber-specific expression pattern associated with the TnI gene. This is the first example in which a contractile protein gene has been shown to rely primarily on an internal regulatory element to elicit transcriptional activation during myogenesis. The diversity of regulatory elements associated with the contractile protein genes suggests that the temporal expression of the genes may involve individual cis-trans regulatory components specific for each gene.
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