ReviewCanadian journal of psychiatry. Revue canadienne de psychiatrie2016
Reframing the Teenage Wasteland: Adolescent Microbiota-Gut-Brain Axis.
Review in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Gut Microbiome in Early Life Stress: A Systematic Review.Nutrients · 2023Pooled it
- Characterizing the Composition of the Pediatric Gut Microbiome: A Systematic Review.Nutrients · 2019Pooled it
- The Adolescent Microbiome-Gut-Brain Axis: Development, Mechanisms, and Translational Perspectives.Nutrients · 2026Review
- Gut microbiota-targeted interventions for depression in adolescents and young adults: Mechanisms, evidence strength and clinical strategies-A narrative review.General psychiatry · 2026Review
- Beyond Psychological Trauma: Associations of Nutritional Status with Depression in Child and Adolescent Victims of Crime.Healthcare (Basel, Switzerland) · 2026Article
- Brief antibiotics exposure during adolescence produces persistent effects on the microbiome and fentanyl-seeking during adulthood in rats.Frontiers in behavioral neuroscience · 2026Article
- Gut microbiota profiles and potential biomarkers in pre-pubertal females with ADHD.Frontiers in microbiology · 2026Article
- Brief exposure to oral antibiotics has age-dependent effects on morphine reward and gene expression in the medial prefrontal cortex of adolescent and adult mice.Brain, behavior, and immunity · 2025Article
- Article
- Examining the healthy human microbiome concept.Nature reviews. Microbiology · 2025Review
- Adolescent alcohol use is associated with differences in the diversity and composition of the oral microbiome.Alcohol, clinical & experimental research · 2024Article
- The Effect of Probiotic Supplementation on the Gut-Brain Axis in Psychiatric Patients.Current issues in molecular biology · 2023Review
- Perspectives on Inequity and Health Disparities in Chile and Their Relationship to Microbial Ecology.mSystems · 2022Article
- A biological framework for emotional dysregulation in alcohol misuse: from gut to brain.Molecular psychiatry · 2021Review
- Animal development in the microbial world: Re-thinking the conceptual framework.Current topics in developmental biology · 2021Article
- Article
- Enduring neurobehavioral effects induced by microbiota depletion during the adolescent period.Translational psychiatry · 2020Article
- Considering the Microbiome in Stress-Related and Neurodevelopmental Trajectories to Schizophrenia.Frontiers in psychiatry · 2020Review
- Is adolescence the missing developmental link in Microbiome-Gut-Brain axis communication?Developmental psychobiology · 2019Review
- The effects of antipsychotic medications on microbiome and weight gain in children and adolescents.BMC medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human adolescence is arguably one of the most challenging periods of development. The young adult is exposed to a variety of stressors and environmental stimuli on a backdrop of significant physiological change and development, which is especially apparent in the brain. It is therefore unsurprising that many psychiatric disorders are first observable during this time. The human intestine is inhabited by trillions of microorganisms, and evidence from both preclinical and clinical research focusing on the established microbiota-gut-brain axis suggests that the etiology and pathophysiology of psychiatric disorders may be influenced by intestinal dysbiosis. Provocatively, many if not all of the challenges faced by the developing teen have a documented impact on these intestinal commensal microbiota. In this review, we briefly summarize what is known about the developing adolescent brain and intestinal microbiota, discuss recent research investigating the microbiota-gut-brain axis during puberty, and propose that pre- and probiotics may prove useful in both the prevention and treatment of psychiatric disorders specifically benefitting the young adult.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.