ArticleExperimental and clinical psychopharmacology2016
Buspirone reduces sexual risk-taking intent but not cocaine self-administration.
Article in Experimental and clinical psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Measuring Sexual Risk-Taking: A Systematic Review of the Sexual Delay Discounting Task.Archives of sexual behavior · 2022Pooled it
- Sexual discounting: A systematic review of discounting processes and sexual behavior.Experimental and clinical psychopharmacology · 2021Pooled it
- Does being drunk or high cause HIV sexual risk behavior? A systematic review of drug administration studies.Pharmacology, biochemistry, and behavior · 2018Pooled it
- Naltrexone-bupropion combinations do not affect cocaine self-administration in humans.Pharmacology, biochemistry, and behavior · 2023Trial
- Buspirone maintenance does not alter the reinforcing, subjective, and cardiovascular effects of intranasal methamphetamine.Drug and alcohol dependence · 2017Trial
- Clinical neuropharmacology of cocaine reinforcement: A narrative review of human laboratory self-administration studies.Journal of the experimental analysis of behavior · 2022Review
- Improving translation of animal models of addiction and relapse by reverse translation.Nature reviews. Neuroscience · 2020Review
- Unpredictability as a modulator of drug self-administration: Relevance for substance-use disorders.Behavioural processes · 2020Review
- Demographic and sexual risk predictors of delay discounting of condom-protected sex.Psychology & health · 2020Article
- Immunopharmacotherapies for Treating Opioid Use Disorder.Trends in pharmacological sciences · 2018Review
- Effects of lorcaserin and buspirone, administered alone and as a mixture, on cocaine self-administration in male and female rhesus monkeys.Experimental and clinical psychopharmacology · 2018Article
- Pharmacotherapies for decreasing maladaptive choice in drug addiction: Targeting the behavior and the drug.Pharmacology, biochemistry, and behavior · 2018Review
- Utility of Nonhuman Primates in Substance Use Disorders Research.ILAR journal · 2017Review
- Effects of Acute and Chronic Treatments with Dopamine DThe Journal of pharmacology and experimental therapeutics · 2017Article
- Insights from Preclinical Choice Models on Treating Drug Addiction.Trends in pharmacological sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Impulsive sexual decision-making may underlie sexual risk-taking behavior that contributes to the disproportionately high prevalence of HIV infection among cocaine users. Delay-discounting procedures measure impulsive decision-making and may provide insight into the underlying mechanisms of sexual risk-taking behavior. The anxiolytic drug buspirone reduces delay discounting in rats and blunts the reinforcing effects of cocaine in some preclinical studies suggesting that it might have utility in the treatment of cocaine-use disorders. This study determined whether buspirone mitigates impulsive risky sexual decision-making in cocaine users on a sexual delay-discounting procedure. The effects of buspirone maintenance on the abuse-related and physiological effects of cocaine were also tested. Nine (N = 9) current cocaine users completed a repeated-measures, inpatient protocol in which sexual delay discounting was assessed after 3 days of maintenance on placebo and buspirone (30 mg/day) in counterbalanced order. The reinforcing, subject-rated, and physiological effects of placebo and intranasal cocaine (15 and 45 mg) were also assessed during buspirone and placebo maintenance. Buspirone increased the likelihood of condom use for hypothetical sexual partners that were categorized as most likely to have a sexually transmitted infection and least sexually desirable. Cocaine functioned as a reinforcer and increased positive subjective effects ratings, but buspirone maintenance did not impact these effects of cocaine. Buspirone was also safe and tolerable when combined with cocaine and may have blunted some its cardiovascular effects. The results from the sexual delay-discounting procedure indicate that buspirone may reduce preference for riskier sex in cocaine users. (PsycINFO Database Record
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.