ArticleEndocrinology2016
Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass.
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In one paragraph
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Membrane-initiated estrogen receptor-α signaling in the hypothalamus regulates trabecular bone in femur in female mice.The Journal of endocrinology · 2026Article
- Advances in the regulation of bone metabolism by central nuclei: a new perspective on the brain-bone axis.Frontiers in neuroscience · 2026Review
- Dynamic changes in Ccn3 expression across the limbic forebrain through the mouse estrous cycle and during lactation.Journal of neuroendocrinology · 2025Article
- Targeting the central and peripheral nervous system to regulate bone homeostasis: mechanisms and potential therapies.Military Medical Research · 2025Review
- A maternal brain hormone that builds bone.Nature · 2024Article
- Bone-organ axes: bidirectional crosstalk.Military Medical Research · 2024Review
- Article
- Interactions between central nervous system and peripheral metabolic organs.Science China. Life sciences · 2022Review
- Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.Annual review of physiology · 2022Review
- Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice.eLife · 2021Article
- Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications.International journal of molecular sciences · 2021Review
- Obesity induced by estrogen deficiency is associated with hypothalamic inflammation.Biochemistry and biophysics reports · 2020Article
- Crosstalk of Brain and Bone-Clinical Observations and Their Molecular Bases.International journal of molecular sciences · 2020Review
- Should We Make More Bone or Not, As Told by Kisspeptin Neurons in the Arcuate Nucleus.Seminars in reproductive medicine · 2019Review
- Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones.Nature communications · 2019Article
- Review
- Regulation of Bone Metabolism by Sex Steroids.Cold Spring Harbor perspectives in medicine · 2018Review
- Cognitive Effects of Aromatase and Possible Role in Memory Disorders.Frontiers in endocrinology · 2018Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
H H FarmanCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
S H WindahlCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
L WestbergCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
H IsakssonCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
E EgeciogluCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
E ScheleCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
H RybergCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
J O JanssonCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
J TuukkanenCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
A KoskelaCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
S K XieCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
L HahnerCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
J ZehrCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
D J CleggCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
M K LagerquistCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
C OhlssonCentre for Bone and Arthritis Research (H.H.F., S.H.W., H.R., M.K.L., C.O.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE413 45 Gothenburg, Sweden; Department of Pharmacology (L.W., E.E.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Biomedical Engineering (H.I.), Lund University, SE221 85 Lund, Sweden; Department of Orthopaedics (H.I.), Clinical Sciences, Lund University, SE221 85 Lund, Sweden; Institute of Neuroscience and Physiology/Endocrinology (E.S., J.O.J.), Sahlgrenska Academy, University of Gothenburg, SE405 30 Gothenburg, Sweden; Department of Clinical Chemistry (H.R.), Sahlgrenska University Hospital, SE413 45 Gothenburg, Sweden; Department of Anatomy and Cell Biology (J.T., A.K.), Institute of Cancer Research and Translational Medicine, Medical Research Center, University of Oulu, FI900 14 Oulu, Finland; and Touchstone Diabetes Center (S.K.X., L.H., J.Z., D.J.C.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
University of Gothenburg · SEThe University of Texas Southwestern Medical Center · USNational Academy of Medicine · USUniversity of Oulu · FILund University · SE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrogens are important regulators of bone mass and their effects are mainly mediated via estrogen receptor (ER)α. Central ERα exerts an inhibitory role on bone mass. ERα is highly expressed in the arcuate (ARC) and the ventromedial (VMN) nuclei in the hypothalamus. To test whether ERα in proopiomelanocortin (POMC) neurons, located in ARC, is involved in the regulation of bone mass, we used mice lacking ERα expression specifically in POMC neurons (POMC-ERα(-/-)). Female POMC-ERα(-/-) and control mice were ovariectomized (OVX) and treated with vehicle or estradiol (0.5 μg/d) for 6 weeks. As expected, estradiol treatment increased the cortical bone thickness in femur, the cortical bone mechanical strength in tibia and the trabecular bone volume fraction in both femur and vertebrae in OVX control mice. Importantly, the estrogenic responses were substantially increased in OVX POMC-ERα(-/-) mice compared with the estrogenic responses in OVX control mice for cortical bone thickness (+126 ± 34%, P < .01) and mechanical strength (+193 ± 38%, P < .01). To test whether ERα in VMN is involved in the regulation of bone mass, ERα was silenced using an adeno-associated viral vector. Silencing of ERα in hypothalamic VMN resulted in unchanged bone mass. In conclusion, mice lacking ERα in POMC neurons display enhanced estrogenic response on cortical bone mass and mechanical strength. We propose that the balance between inhibitory effects of central ERα activity in hypothalamic POMC neurons in ARC and stimulatory peripheral ERα-mediated effects in bone determines cortical bone mass in female mice.
Indexed as
AnimalsArcuate Nucleus of HypothalamusBone DensityCortical BoneEstrogen Receptor alphaEstrogensFemaleHypothalamusMiceMice, KnockoutNeuronsPro-OpiomelanocortinEstrogen Receptor alphaEstrogensPro-Opiomelanocortin
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