ArticleEndocrinology2016
Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs.
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Long-term, Dynamic Remodelling of the Corticotroph Transcriptome and Excitability After a Period of Chronic Stress.Endocrinology · 2024Article
- Looking Back to Move Forward: Research in Stress, Behavior, and Immune Function.Neuroimmunomodulation · 2024Review
- Conversion of spikers to bursters in pituitary cell networks: Is it better to disperse for maximum exposure or circle the wagons?PLoS computational biology · 2024Article
- Sex differences in pituitary corticotroph excitability.Frontiers in physiology · 2023Article
- Fast dynamics in the HPA axis: Insight from mathematical and experimental studies.Current opinion in endocrine and metabolic research · 2022Review
- Molecular Derangements and the Diagnosis of ACTH-Dependent Cushing's Syndrome.Endocrine reviews · 2022Review
- Glucocorticoid action in the anterior pituitary gland: Insights from corticotroph physiology.Current opinion in endocrine and metabolic research · 2022Review
- The Mechanisms Underlying Autonomous Adrenocorticotropic Hormone Secretion in Cushing's Disease.International journal of molecular sciences · 2020Review
- Stress experience and hormone feedback tune distinct components of hypothalamic CRH neuron activity.Nature communications · 2019Article
- A computational model for gonadotropin releasing cells in the teleost fish medaka.PLoS computational biology · 2019Article
- Magnocellular Vasopressin and the Mechanism of "Glucocorticoid Escape".Frontiers in endocrinology · 2019Review
- Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility.Stress (Amsterdam, Netherlands) · 2018Review
- Common and diverse elements of ion channels and receptors underlying electrical activity in endocrine pituitary cells.Molecular and cellular endocrinology · 2018Review
- Article
- Heterogeneity of Calcium Responses to Secretagogues in Corticotrophs From Male Rats.Endocrinology · 2017Article
- Modeling the diversity of spontaneous and agonist-induced electrical activity in anterior pituitary corticotrophs.Journal of neurophysiology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Corticotroph cells from the anterior pituitary are an integral component of the hypothalamic-pituitary-adrenal (HPA) axis, which governs the neuroendocrine response to stress. Corticotrophs are electrically excitable and fire spontaneous single-spike action potentials and also display secretagogue-induced bursting behavior. The HPA axis function is dependent on effective negative feedback in which elevated plasma glucocorticoids result in inhibition at the level of both the pituitary and the hypothalamus. In this study, we have used an electrophysiological approach coupled with mathematical modeling to investigate the regulation of spontaneous and CRH/arginine vasopressin-induced activity of corticotrophs by glucocorticoids. We reveal that pretreatment of corticotrophs with 100 nM corticosterone (CORT; 90 and 150 min) reduces spontaneous activity and prevents a transition from spiking to bursting after CRH/arginine vasopressin stimulation. In addition, previous studies have identified a role for large-conductance calcium- and voltage-activated potassium (BK) channels in the generation of secretagogue-induced bursting in corticotrophs. Using the dynamic clamp technique, we demonstrated that CRH-induced bursting can be switched to spiking by subtracting a fast BK current, whereas the addition of a fast BK current can induce bursting in CORT-treated cells. In addition, recordings from BK knockout mice (BK(-/-)) revealed that CORT can also inhibit excitability through BK-independent mechanisms to control spike frequency. Thus, we have established that glucocorticoids can modulate multiple properties of corticotroph electrical excitability through both BK-dependent and BK-independent mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.